1-(tert-Butoxycarbonyl)-2-pyrrolidinone

Suppliers

Names

[ Name ]:
1-(tert-Butoxycarbonyl)-2-pyrrolidinone

[Synonym ]:
MFCD00674099
1-Pyrrolidinecarboxylic acid, 2-oxo-, 1,1-dimethylethyl ester
tert-Butyl 2-oxo-1-pyrrolidinecarboxylate
tert-Butyl 2-oxopyrrolidine-1-carboxylate
2-Methyl-2-propanyl 2-oxo-1-pyrrolidinecarboxylate
N-boc-1-azacyclopentan-2-one
1-Pyrrolidinecarboxylicacid, 2-oxo-, 1,1-dimethylethyl ester

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
302.7±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₅NO₃

[ Molecular Weight ]:
185.220

[ Flash Point ]:
136.9±19.3 °C

[ Exact Mass ]:
185.105194

[ PSA ]:
46.61000

[ LogP ]:
0.03

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.486

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Pyrrolidinone
Di-tert-butyl dicarbonate
Carbamic acid, 4-pentenyl-, 1,1-dimethylethyl ester (9CI)
Tert-Butyl N-(4-Hydroxybutyl)Carbamate
Boc-GABA-OH
Di-tert-butyl carbonate
2-Methyl-2-propanyl 1-pyrrolidinecarboxylate
chromium trioxide
1-Boc-(R)-(-)-3-Hydroxypyrrolidine

DownStream

1-Pyrrolidinecarboxylicacid,2-ethoxy-,1,1-dimethylethylester(9CI)
Boc-GABA-OH
tert-butyl 2-methoxypyrrolidine-1-carboxylate
4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester
ethyl 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
iso-propyl-(4-tert-butoxycarbonyl)aminobutyrate
2-Pyrrolidinone
Isobutylene
2-Methyl-2-propanyl 1-pyrrolidinecarboxylate
tert-Butyl 2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate

Articles

Kinetics of elimination of several heterocyclic carbamates in the gas phase. Brusco Y, et al.

J. Phys. Org. Chem. 15(12) , 796-800, (2002)

1-(tert-Butoxycarbonyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid
1-(tert-butoxycarbonyl)-2,6-di(thien-2-yl)-1,4-dihydropyridine
1-(tert-butoxycarbonyl)-2,6-diphenyl-1,4-dihydropyridine
1-(TERT-BUTOXYCARBONYL)-2-(4-CYANOPHENYL)INDOLE
1-(TERT-BUTOXYCARBONYL)-2,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC ACID
(1-(tert-Butoxycarbonyl)-2,2,4-triMethyl-1,2-dihydroquinolin-6-yl)boronic acid
2-({2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3-dimethylbutanamido]ethyl}sulfanyl)acetic acid
3-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]-2-hydroxypropanoic acid
rac-2-({[(1R,2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cycloheptyl]formamido}oxy)acetic acid
rac-3-{1-[(1R,2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cycloheptyl]-N-methylformamido}-2-methylpropanoic acid
rac-2-{[(1R,2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cycloheptyl]formamido}pent-4-ynoic acid
(2S)-2-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]pentanamido}butanoic acid
3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoropropanamido]propanoic acid
1-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexanecarbonyl}pyrrolidine-3-carboxylic acid
2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5,5-dimethylhexanamido]-2-methylbutanoic acid
2-[N-(cyclopropylmethyl)-6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylhexanamido]acetic acid

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