thenalidine

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Names

[ CAS No. ]:
86-12-4

[ Name ]:
thenalidine

[Synonym ]:
N-(1-Methyl-[4]piperidyl)-N-[2]thienylmethyl-anilin
1-Methyl-4-N-2-thenylanilinopiperidine
Sandosten (4-Amino-1-methyl-N'-phenyl-N'-then-2-yl-piperidin-tartrat)
Sanbosten
Tenalidina [INN-Spanish]
N-(1-methyl-[4]piperidyl)-N-[2]thienylmethyl-aniline
Thenalidinum
Thenalidinum [INN-Latin]
Tenalidina
thenalidine
1-Methyl-4-<phenyl-<2-thenyl-amino>-piperidin
Thenophenopiperidine
N-Methyl-4-(N-thenyl-2-anilino)-piperidin
Thenaldine
1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine

Chemical & Physical Properties

[ Density]:
1.14g/cm3

[ Boiling Point ]:
413.9ºC at 760 mmHg

[ Melting Point ]:
95-97°

[ Molecular Formula ]:
C₁₇H₂₂N₂S

[ Molecular Weight ]:
286.43500

[ Flash Point ]:
204.1ºC

[ Exact Mass ]:
286.15000

[ PSA ]:
34.72000

[ LogP ]:
3.78680

[ Index of Refraction ]:
1.619

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN1400000

CHEMICAL NAME :: Piperidine, 1-methyl-4-(N-2-thenylanilino)-

CAS REGISTRY NUMBER :: 86-12-4

BEILSTEIN REFERENCE NO. :: 0244448

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H22-N2-S

MOLECULAR WEIGHT :: 286.47

WISWESSER LINE NOTATION :: T6NTJ A1 DNR&1- BT5SJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEWEAC Medizinische Welt. (F.K. Schattauer Verlag, Postfach 2945, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1-18, 1927-1944; V.1- 1950- Volume(issue)/page/year: 17,2791,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Bromobenzene
1-methyl-4-([2]thienylmethyl-amino)-piperidine
2-chloromethyl thiophene
N-(1-METHYLPIPERIDIN-4-YL)ANILINE

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Thenalidine
THENALIDINE MALEATE
THENALIDINE TARTRATE
N-(2,2-Dimethoxyethyl)-Na(2)-[5-(methylthio)-1,3,4-thiadiazol-2-yl]-N-propylurea
N-[2-[(2,2-Diphenylethyl)thio]ethyl]-Na(2)-[3-(1H-imidazol-5-yl)propyl]guanidine
1H-Imidazole-2-acetic acid, 5-[3-[(methylsulfonyl)amino]phenyl]-, ethyl ester
1-[(3,4-Dihydro-2H-1-benzopyran-8-yl)oxy]-3-[(1-methylethyl)amino]-2-propanol
1-[4-Chloro-3-(trifluoromethyl)phenyl]-4-(tetrahydro-2H-pyran-2-yl)piperazine
tert-butyl N-[(2R)-1-(cyclohex-1-en-1-yl)-1-oxopropan-2-yl]carbamate
tert-butyl N-{4-[2-(4-hydroxyphenyl)propan-2-yl]phenyl}carbamate
2-[(5-Chloro-2-fluorophenyl)methyl]oxirane
2-{[3-bromo-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)phenyl]formamido}-2-cyclopropylacetic acid
3-{[(3-Methylfuran-2-yl)methyl]sulfanyl}pentanenitrile

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