Amodiaquine
Suppliers
Names
[ CAS No. ]:
86-42-0
[ Name ]:
Amodiaquine
[Synonym ]:
4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol
SN 10,751
CAM-AQI
Camoquinal
4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
Camoquine
EINECS 201-669-3
4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino) methyl]phenol
MFCD00552927
Camoquin
Flavoquine
Miaquin
Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-
aminodiaquine
Amodiaquine
Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-
CAM-AQ1
Camochin
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
478.0±45.0 °C at 760 mmHg
[ Melting Point ]:
208°C
[ Molecular Formula ]:
C20H22ClN3O
[ Molecular Weight ]:
355.861
[ Flash Point ]:
242.9±28.7 °C
[ Exact Mass ]:
355.145142
[ PSA ]:
48.39000
[ LogP ]:
4.77
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.669
[ Storage condition ]:
-20°C Freezer
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GO7300000
- CHEMICAL NAME :
- o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-
- CAS REGISTRY NUMBER :
- 86-42-0
- BEILSTEIN REFERENCE NO. :
- 0300962
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C20-H22-Cl-N3-O
- MOLECULAR WEIGHT :
- 355.90
- WISWESSER LINE NOTATION :
- T66 BNJ EMR DQ C1N2&2& IG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 72 mg/kg/7W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - pulmonary emboli Liver - other changes Blood - agranulocytosis
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 20 mg/kg/25D-I
- TOXIC EFFECTS :
- Blood - thrombocytopenia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 29 mg/kg/25D-I
- TOXIC EFFECTS :
- Blood - thrombocytopenia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 225 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 5 mg/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,311,1989
Safety Information
[ Safety Phrases ]:
S22-S24/25-S8
[ WGK Germany ]:
3
[ HS Code ]:
2933499090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%