1-(3-methyl-2-nitro-phenoxy)-3-(tert-butylamino)propan-2-ol

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Names

[ CAS No. ]:
86166-58-7

[ Name ]:
1-(3-methyl-2-nitro-phenoxy)-3-(tert-butylamino)propan-2-ol

[Synonym ]:
dl-zami-1305

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₂N₂O₄

[ Molecular Weight ]:
282.33500

[ Exact Mass ]:
282.15800

[ PSA ]:
87.31000

[ LogP ]:
2.94510

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA8470000

CHEMICAL NAME :: 2-Propanol, 1-(tert-butylamino)-3-(3-methyl-2-nitrophenoxy)-, DL-

CAS REGISTRY NUMBER :: 86166-58-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C14-H22-N2-O4

MOLECULAR WEIGHT :: 282.38

WISWESSER LINE NOTATION :: WNR B1 FO1YQ1MX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76243 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 gm/kg/26W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/26W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 13,18,1985 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,395,1986

Related Compounds

4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
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1-Methyl-3-[(oxan-4-yl)methyl]piperazine
2-(2,3-Dimethoxyphenyl)-1-methylpiperazine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
(R)-3,3'-Di(pyridin-2-yl)-1,1'-binapthyl-2,2'-diyl hydrogenphosphate dihydrochloride
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
N1-(3-chloro-2-methylphenyl)-N2-(2-(1-methyl-1H-indol-5-yl)ethyl)oxalamide
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-((3-(tetrahydro-2H-pyran-4-yl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide