1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid

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Names

[ CAS No. ]:
862574-88-7

[ Name ]:
1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid

[Synonym ]:
Cyclopropanecarboxylic acid, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-
1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid
1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid
1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
331.1±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H8F2O4

[ Molecular Weight ]:
242.176

[ Flash Point ]:
154.0±27.9 °C

[ Exact Mass ]:
242.039063

[ PSA ]:
55.76000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.588

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile
  • Methyl tert-butyl ether
  • Dicyclohexylamine
  • 2-[2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-6-methylpyran-4-ylidene]propanedinitrile
  • 5-Bromo-2,2-difluorobenzodioxole
  • 2,2-Difluorobenzodioxole-5-carboxylic acid
  • (2,2-Difluoro-1,3-benzodioxol-5-yl)methanol
  • 5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

DownStream

  • 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID HYDROCHLORIDE
  • Tezacaftor(VX-661)

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%