Dasatinib monohydrate

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Names

[ CAS No. ]:
863127-77-9

[ Name ]:
Dasatinib monohydrate

[Synonym ]:
Dasatinib
SPRYCEL (TN)
Dasatinibmonohydrate
N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-1,3-thiazole-5-carboxamide monohydrate
UNII-RBZ1571X5H
N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide hydrate (1:1)
N-(2-chloro-6-methylphenyl)-2-(6-(4-(3-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide monohydrate
cc-335
Dasatinib hydrate
N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide hydrate (1:1)
5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrate (1:1)
Dasatinib hydrate (JAN)
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate
Dasatinib monohydrate
dasatinib.H2O
MFCD08704581

Chemical & Physical Properties

[ Density]:
1.408 g/cm3

[ Melting Point ]:
97-99 °C(lit.)

[ Molecular Formula ]:
C22H28ClN7O3S

[ Molecular Weight ]:
506.021

[ Exact Mass ]:
505.166290

[ PSA ]:
143.98000

[ LogP ]:
3.39810

[ Water Solubility ]:
MAY DECOMPOSE

Safety Information

[ Hazard Codes ]:
C,Xi

[ Risk Phrases ]:
R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3263 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
QD8530000

[ Packaging Group ]:
II

[ Hazard Class ]:
4.3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-(2-Hydroxyethyl)piperazine
  • N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
  • Dasatinib (BMS-354825)

DownStream

  • Dasatinib (BMS-354825)

Related Compounds

  • Dasatinib (BMS-354825)
  • Dasatinib Impurity 15
  • Dasatinib N-Oxide
  • Dasatinib (hydrochloride)
  • Dasatinib Carboxylic Acid Ethyl Ester
  • Dasatinib Dimeric Impurity
  • N-(3-methylpiperidin-4-yl)-2-nitrobenzene-1-sulfonamide
  • (R)-N-(5-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
  • (S)-N-(5-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
  • 4-{[(1,3-Oxazol-4-yl)methoxy]methyl}piperidine
  • (1-Benzylpyrrol-2-yl)oxy-tert-butyl-dimethylsilane
  • 5-Bromo-1-isobutyl-1H-indole-2-carboxylic acid ethyl ester
  • 5-Bromo-1-(2-methoxyethyl)-1H-indole-2-carboxylic acid
  • (3-Bromophenyl)(3-(fluoromethyl)azetidin-1-yl)methanone
  • N-(4,4-difluorocyclohexyl)-1-ethyl-1H-pyrazole-3-carboxamide
  • 1-(1-((5-Ethylthiophen-2-yl)sulfonyl)azetidin-3-yl)piperidine-4-carboxamide
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