Dasatinib monohydrate

Suppliers

Names

[ CAS No. ]:
863127-77-9

[ Name ]:
Dasatinib monohydrate

[Synonym ]:
Dasatinib
SPRYCEL (TN)
Dasatinibmonohydrate
N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-1,3-thiazole-5-carboxamide monohydrate
UNII-RBZ1571X5H
N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide hydrate (1:1)
N-(2-chloro-6-methylphenyl)-2-(6-(4-(3-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide monohydrate
cc-335
Dasatinib hydrate
N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide hydrate (1:1)
5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrate (1:1)
Dasatinib hydrate (JAN)
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate
Dasatinib monohydrate
dasatinib.H2O
MFCD08704581

Chemical & Physical Properties

[ Density]:
1.408 g/cm3

[ Melting Point ]:
97-99 °C(lit.)

[ Molecular Formula ]:
C22H28ClN7O3S

[ Molecular Weight ]:
506.021

[ Exact Mass ]:
505.166290

[ PSA ]:
143.98000

[ LogP ]:
3.39810

[ Water Solubility ]:
MAY DECOMPOSE

Safety Information

[ Hazard Codes ]:
C,Xi

[ Risk Phrases ]:
R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3263 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
QD8530000

[ Packaging Group ]:
II

[ Hazard Class ]:
4.3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-(2-Hydroxyethyl)piperazine
  • N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
  • Dasatinib (BMS-354825)

DownStream

  • Dasatinib (BMS-354825)

Related Compounds

  • Dasatinib (BMS-354825)
  • Dasatinib Impurity 15
  • Dasatinib N-Oxide
  • Dasatinib (hydrochloride)
  • Dasatinib Carboxylic Acid Ethyl Ester
  • Dasatinib Dimeric Impurity
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine