2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

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Names

[ CAS No. ]:
86404-63-9

[ Name ]:
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

[Synonym ]:
1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
2',4'-Difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone
2',4'-Difluoro-2-(1H-1,2,4-triazolyl)acetophenone
T5NN DNJ A1VR BF DF
Ethanone, 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-
1-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-yl)ethanone
MFCD02093825
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
388.0±52.0 °C at 760 mmHg

[ Melting Point ]:
103-107 °C(lit.)

[ Molecular Formula ]:
C10H7F2N3O

[ Molecular Weight ]:
223.18

[ Flash Point ]:
188.5±30.7 °C

[ Exact Mass ]:
223.055725

[ PSA ]:
47.78000

[ LogP ]:
0.34

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.593

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
R36/37/38

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2,4-Triazole
  • 2-Chloro-2',4'-difluoroacetophenone
  • triazole
  • 1,3-Difluorobenzene
  • 2-Bromo-2',4'-difluoroacetophenone
  • 1-[[(2R,3R)-2-(2,4-Difluorophenyl)-3-methyl-2-oxiranyl]methyl]-1H-1,2,4-triazole

DownStream

  • 3-(6-CHLORO-5-FLUOROPYRIMIDIN-4-YL)-2,(2,4-DIFLUORO PHENYL)-1-(1H-1,2,4-TRIAZOLE-1-YL)BUTAN-2-OL HYDROCHLORIDE
  • Fluconazole
  • 1-{[2-(2,4-DIFLUOROPHENYL)OXIRAN-2-YL]METHYL}-1H-1,2,4-TRIAZOLE
  • rac-6-Chloro Voriconazole
  • 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol
  • Voriconazole
  • (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%