Empagliflozin (BI 10773)

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Names

[ Name ]:
Empagliflozin (BI 10773)

[Synonym ]:
X5927
Empagliflozin
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-, (1S)-
Jardiance
CS-0940
BI10773
(1S)-1,5-Anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydro-3-furanyloxy]benzyl}phenyl)-D-glucitol

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
664.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₇ClO₇

[ Molecular Weight ]:
450.909

[ Flash Point ]:
355.7±31.5 °C

[ Exact Mass ]:
450.144531

[ PSA ]:
108.61000

[ LogP ]:
3.38

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.628

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Methyl 1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-alpha-D-glucopyranoside
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one
Fluorobenzene
2-Chloro-5-iodobenzoic acid
2-Chloro-4'-fluoro-5-iodobenzophenone
(2-CHLORO-5-IODOPHENYL)[4-[[(3S)-TETRAHYDRO-3-FURANYL)OXY]PHENYL]METHANONE