N-Hydroxyacetyldemecolcine

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Names

[ Name ]:
N-Hydroxyacetyldemecolcine

[Synonym ]:
N-Methylcolchifoline
N-(hydroxyacetyl)demecolcine
Democolcine,N-hydroxyacetyl
2-hydroxy-n-methyl-n-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
Acetamide,2-hydroxy-N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
723ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₇NO₇

[ Molecular Weight ]:
429.46300

[ Flash Point ]:
391.1ºC

[ Exact Mass ]:
429.17900

[ PSA ]:
94.53000

[ LogP ]:
2.18620

[ Index of Refraction ]:
1.599

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC3662400

CHEMICAL NAME :: Acetamide, 2-hydroxy-N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tet ramethoxy-9-oxobenzo( a) heptalen-7-yl)-

CAS REGISTRY NUMBER :: 86436-33-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H27-N-O7

MOLECULAR WEIGHT :: 429.51

WISWESSER LINE NOTATION :: T B677 MV&T&J CO1 DO1 EO1 JN1&V1Q NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6228 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(-)-Demecolcine
(trifluoroacetyl)glycolyl chloride

DownStream

Related Compounds

N,N'-bis[2-(3,4-dimethoxyphenyl)ethyl]-N,N'-dimethylpropane-1,3-diamine
N-octanoyl benzotriazole
N-[4-[(6-chloro-[1,3]dioxolo[4,5-b]acridin-10-yl)amino]-3-methoxyphenyl]methanesulfonamide
N-(diaminomethylidene)pyrrolidine-1-carboximidamide,hydrochloride
N-phenyl-[1,3]dioxolo[4,5-b]acridin-10-amine
N-[bis(diethylamino)silyl]-N-ethylethanamine
3-Tert-butyl-4-(cyclopropylmethyl)phenol
4-Cyclopropoxy-N2,N2-dimethylpyridine-2,6-diamine
3-Cyclopropoxy-4-ethylbenzenesulfonamide
2-(Cyclopropylmethoxy)-3-hydroxybenzenesulfonamide
2-(Cyclohexylmethyl)-6-(methylamino)phenol
3-Cyclopropoxy-5-ethyl-N-methylpicolinamide
5-Cyclopropoxy-N2,N2,N4,N4-tetramethylpyridine-2,4-dicarboxamide
N-(5-Cyclopropoxy-2-(dimethylamino)pyridin-3-YL)methanesulfonamide
2-Tert-butoxy-3-tert-butyl-4-cyclopropoxypyridine
3-Cyclopropoxy-2-formylbenzenesulfonamide

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