N-(Phenoxyacetyl)deacetylcolchicine

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Names

[ CAS No. ]:
86436-45-5

[ Name ]:
N-(Phenoxyacetyl)deacetylcolchicine

[Synonym ]:
2-Phenoxy-N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
N-(Phenoxyacetyl)deacetylcolchicine
Acetamide,2-phenoxy-N-(5,6,7,9-tetrahydro-9-oxo-1,2,3,10-tetramethoxybenzo(a)heptalen-7-yl)-,(S)

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
807.8ºC at 760 mmHg

[ Molecular Formula ]:
C28H29NO7

[ Molecular Weight ]:
491.53200

[ Flash Point ]:
442.3ºC

[ Exact Mass ]:
491.19400

[ PSA ]:
92.32000

[ LogP ]:
4.32160

[ Index of Refraction ]:
1.612

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC7670000
CHEMICAL NAME :
Acetamide, 2-phenoxy-N-(5,6,7,9-tetrahydro-9-oxo-1,2,3,10-tetram ethoxybenzo(a)heptale n- 7-yl)-, (S)-
CAS REGISTRY NUMBER :
86436-45-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C28-H29-N-O7
MOLECULAR WEIGHT :
491.58
WISWESSER LINE NOTATION :
T B677 MV&T&J CO1 DO1 EO1 JMV1OR& NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Phenoxyacetic anhydride
  • Trimethylcolchicinic acid methyl ether

DownStream

Related Compounds

  • N-phenoxyacetyl-N'-thiocarbamoyl-hydrazine
  • N-Phenoxyacetyl-aethylendiamin
  • Glycine,N-(phenoxyacetyl)- (6CI,7CI,8CI,9CI)
  • 5-Chloro-N-(phenoxyacetyl)anthranilic acid
  • N-[9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-[(2-phenoxyacetyl)amino]purin-6-yl]-2-phenoxyacetamide
  • (R)-3-amino-N-phenoxyacetyl-4-phenylbutanone
  • 2-Bromo-5-ethyl-4-nitropyridine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide