ditert-butyl 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate

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Names

[ CAS No. ]:
86669-33-2

[ Name ]:
ditert-butyl 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate

[Synonym ]:
methotrexate di-t-butyl ester
Methotrexate dibutyl esters
DITERT-BUTYL 2-[[4-[(2,4-DIAMINOPTERIDIN-6-YL)METHYL-METHYL-AMINO]BENZOYL]AMINO]PENTANEDIOATE

Chemical & Physical Properties

[ Density]:
1.271g/cm3

[ Molecular Formula ]:
C28H38N8O5

[ Molecular Weight ]:
566.65200

[ Exact Mass ]:
566.29700

[ PSA ]:
188.54000

[ LogP ]:
4.33590

[ Index of Refraction ]:
1.619

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • H-Glu(OtBu)-OtBu.HCl
  • 4-Amino-4-deoxy-10-methylpteroic acid
  • 2,4-Pteridinediamine,6-methyl-

DownStream

  • Methotrexate

Related Compounds

  • 3-(3-Fluorothiophen-2-yl)-1,4-dimethyl-1H-pyrazol-5-amine
  • 3-(3-Fluorothiophen-2-yl)-1-methyl-1H-pyrazol-5-amine
  • 4-[(2-Chloro-6-methyl-4-pyridinyl)methyl]morpholine
  • 2-[(But-3-yn-1-yl)amino]-1,3-thiazole-4-carboxylic acid
  • (3,3-Difluoro-2-methylbutyl)(methyl)amine
  • 1-(5-Bromofuran-2-yl)pyrrolidine
  • (S)-5-(1-amino-2,2-dimethylpropyl)-2-methylaniline
  • 4-Amino-6-(3-fluorothiophen-2-yl)-1,3,5-triazine-2-thiol
  • 5-(5-(2-aminoethyl)-1,2,4-oxadiazol-3-yl)pyrimidine-2,4(1H,3H)-dione
  • (I+/-R,I(2)R)-I(2)-Amino-I+/--methyl-1H-indole-6-ethanol
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