H-Cys-OEt.HCl

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Names

[ CAS No. ]:
868-59-7

[ Name ]:
H-Cys-OEt.HCl

[Synonym ]:
L-Cysteine Ethyl Ester HCl
EINECS 212-779-6
Cystanin
DL-cysteine ethyl ester hydrochloride
L-Cysteine, ethyl ester, hydrochloride (1:1)
MFCD00012631
Ethyl L-cysteinate hydrochloride (1:1)
E-Cysten
H-CYS-OET
H-Cys-OEt.HCl
L-Cysteine ethyl est
L-Cysteineethylesterhydrochloride
Ethyl cysteine hydrochloride
ethyl L-cysteinate hydrochloride

Chemical & Physical Properties

[ Density]:
1.391 g/cm3

[ Boiling Point ]:
205.9ºC at 760 mmHg

[ Melting Point ]:
123-125 °C(lit.)

[ Molecular Formula ]:
C5H12ClNO2S

[ Molecular Weight ]:
185.672

[ Flash Point ]:
78.3ºC

[ Exact Mass ]:
185.027725

[ PSA ]:
91.12000

[ LogP ]:
1.30890

[ Index of Refraction ]:
-11.5 ° (C=8, 1mol/L HCl)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA1820000
CHEMICAL NAME :
Cysteine, ethyl ester, hydrochloride, L-
CAS REGISTRY NUMBER :
868-59-7
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C5-H11-N-O2-S.Cl-H
MOLECULAR WEIGHT :
185.69
WISWESSER LINE NOTATION :
SH1YZVO2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,113,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,113,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
725 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,113,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,113,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
854 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 20,721,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,113,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
688 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,113,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
HA1820000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethanol
  • L-Cysteine hydrochloride anhydrous
  • L-cysteine

DownStream

  • N-(3-nitratopivaloyl)cysteine ethyl ester
  • ethyl 2-phenyl-4,5-dihydrothiazole-4-carboxylate
  • ethyl 2-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]-4,5-dihydro-1,3-thiazole-4-carboxylate
  • 2-Benzothiazole carboxylic acid,6-hydroxy-,ethylester(9CI)
  • ethyl 4,5-dihydro-1,3-thiazole-4-carboxylate
  • N-phenylmethoxybenzamide
  • (H-Cys-OEt)2.2HCl
  • benzoic acid

Articles

GC-MS analysis of S-nitrosothiols after conversion to S-nitroso-N-acetyl cysteine ethyl ester and in-injector nitrosation of ethyl acetate.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(28) , 3442-55, (2009)

S-Nitrosothiols from low-molecular-mass and high-molecular-mass thiols, including glutathione, albumin and hemoglobin, are endogenous potent vasodilators and inhibitors of platelet aggregation. By uti...

Effect of cysteine ethylester hydrochloride (Cystanin) on host defense mechanisms (V): Potentiation of nitroblue tetrazolium reduction and chemiluminescence in macrophages or leukocytes of mice or rats.

Jpn. J. Pharmacol. 53(1) , 57-66, (1990)

L-Cysteine ethylester hydrochloride (Cystanin, ethylcysteine) at doses of 3-30 mg/kg, p.o., potentiated the reduction of nitroblue tetrazolium (NBT) by mouse peritoneal macrophages ex vivo. In in vitr...

Oral L-cysteine ethyl ester (LCEE) reduces amoebic gill disease (AGD) in Atlantic salmon Salmo salar.

Dis. Aquat. Organ. 66(1) , 21-8, (2005)

There is a need for the development of alternative therapeutic treatments for amoebic gill disease (AGD) in Atlantic salmon Salmo salar L. to maintain the sustainability of the Tasmanian Atlantic salm...


More Articles

Related Compounds

  • (H-Cys-Phe-OH)2 (Disulfide bond)
  • h-cys(ch3bzl)-ol
  • H-Cys(Acm)(O)-OH
  • H-Cys(Trt)-Ala-Leu-OMe
  • H-Cys(Acm)-OH HCl
  • H-Cys(Et)-OH
  • N-[(2-methoxyadamantan-2-yl)methyl]thiophene-2-sulfonamide
  • 3-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-N-(2-(6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl)ethyl)propanamide
  • N-(4-methyl-1,2,5-oxadiazol-3-yl)-3-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)propanamide
  • 1-(6-(1H-1,2,4-triazol-1-yl)pyridazin-3-yl)-N-(thiazolo[3,2-b][1,2,4]triazol-6-ylmethyl)piperidine-3-carboxamide
  • (1-(6-(1H-1,2,4-triazol-1-yl)pyridazin-3-yl)piperidin-3-yl)(4-(cyclopropylsulfonyl)piperazin-1-yl)methanone
  • 1-(6-(1H-1,2,4-triazol-1-yl)pyridazin-3-yl)-N-(6-methoxypyridin-3-yl)piperidine-3-carboxamide
  • 1-(benzo[d]isoxazol-3-yl)-N-(3-methylisoxazol-5-yl)methanesulfonamide
  • (4-(6-(1H-1,2,4-triazol-1-yl)pyridazin-3-yl)piperazin-1-yl)(2-ethoxypyridin-3-yl)methanone
  • 3-(4-((3,5-difluorophenyl)sulfonyl)piperazin-1-yl)-6-(1H-1,2,4-triazol-1-yl)pyridazine
  • methyl 4-((4-((4-methyl-4H-1,2,4-triazol-3-yl)sulfonyl)piperidin-1-yl)sulfonyl)benzoate
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