(1E,4E)-8-chloro-4-((dimethylamino)Methylene)-1-(2-fluoro-6-Methoxyphenyl)-3,4-dihydrobenzo[c]azepin-5-one

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Names

[ CAS No. ]:
869367-33-9

[ Name ]:
(1E,4E)-8-chloro-4-((dimethylamino)Methylene)-1-(2-fluoro-6-Methoxyphenyl)-3,4-dihydrobenzo[c]azepin-5-one

[Synonym ]:
3H-2-Benzazepine,4,5-dibromo-8-chloro-4,5-dihydro-1-phenyl
8-chloro-4,5-dibromo-4,5-dihydro-1-phenyl-3H-2-benzazepine

Chemical & Physical Properties

[ Molecular Formula ]:
C20H18ClFN2O2

[ Molecular Weight ]:
372.82100

[ Exact Mass ]:
372.10400

[ PSA ]:
41.90000

[ LogP ]:
3.40250

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • TERT-BUTYL (3-(4-CHLORO-2-(2-FLUORO-6-METHOXYBENZOYL)PHENYL)PROP-2-YN-1-YL)CARBAMATE
  • N,N-Dimethylformamide dimethyl acetal
  • (5-Chloro-2-iodophenyl)(2,6-difluorophenyl)methanone
  • (2-Amino-5-chlorophenyl)(2,6-difluorophenyl)methanone
  • (5-CHLORO-2-IODOPHENYL)(2-FLUORO-6-METHOXYPHENYL)METHANONE

DownStream

  • Alisertib (MLN8237)