2-Methyl-2-propanyl 1-pyrrolidinecarboxylate

Names

[ CAS No. ]:
86953-79-9

[ Name ]:
2-Methyl-2-propanyl 1-pyrrolidinecarboxylate

[Synonym ]:
tert-butyl pyrrolidine-1-carboxylate
MFCD00216581

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
221.4±9.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₇NO₂

[ Molecular Weight ]:
171.237

[ Flash Point ]:
87.7±18.7 °C

[ Exact Mass ]:
171.125931

[ PSA ]:
29.54000

[ LogP ]:
1.49

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.473

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NA 1993 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Pyrrolidine
Di-tert-butyl dicarbonate
N-BOC-Pyrrole
Boc-L-Proline
3-Pyrroline
Boc-NH-C4-Br
Carbonazidic acid,1,1-dimethylethyl ester
Pyrrole
1-(tert-Butoxycarbonyl)-2-pyrrolidinone
tert-butyl 2,5-dioxopyrrolidine-1-carboxylate

DownStream

Boc-GABA-OH
tert-butyl 2-methoxypyrrolidine-1-carboxylate
Boc-D-Pro-OH
Boc-L-Proline
2-(2,9,9-TriMethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-pyrrolidine
Pyrrolidine
Isobutylene
1-(tert-Butoxycarbonyl)-2-pyrrolidinone
tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate
1-Pyrrolidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1,1-dimethylethyl ester, (2S)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications.

J. Org. Chem. 76(15) , 5936-53, (2011)

A comprehensive study of the enantioselective Pd-catalyzed α-arylation of N-Boc pyrrolidine has been carried out. The protocol involves deprotonation of N-Boc pyrrolidine using s-BuLi/(-)-sparteine in...

Asymmetric synthesis of enantioenriched (+)-elaeokanine A.

J. Org. Chem. 71(15) , 5674-8, (2006)

The key transformation in the total synthesis of (+)-elaeokanine A was accomplished by asymmetric deprotonation of N-Boc pyrrolidine, followed by the reaction of the in situ generated enantioenriched ...

Enantioselective, palladium-catalyzed α-arylation of N-boc-pyrrolidine. Campos KR, et al.

J. Am. Chem. Soc. 128(11) , 3538-3539, (2006)

2-Methyl-2-propanyl 3-(methoxymethyl)-1-pyrrolidinecarboxylate
2-Methyl-2-propanyl 3-(methylamino)-1-pyrrolidinecarboxylate hydrochloride (1:1)
2-Methyl-2-propanyl 3-(methylsulfonyl)-1-pyrrolidinecarboxylate
2-Methyl-2-propanyl 3-methyl-1-pyrrolidinecarboxylate
2-Methyl-2-propanyl 3-(cyanoacetyl)-1-pyrrolidinecarboxylate
2-Methyl-2-propanyl 3-(trifluoromethoxy)-1-pyrrolidinecarboxylate
2-[[(3,5-Dimethyl-4-isoxazolyl)methyl]thio]ethanamine
2-(Chloromethyl)-3-methylfuran
2-[(3,3-Dimethylbutyl)amino]ethan-1-olhydrochloride
Peroxide, benzoyl 1-oxohexadecyl
Acetamide, 2-[[3-[[4-(1-methylethyl)phenoxy]methyl]-1H-1,2,4-triazol-5-yl]thio]-N-[4-(2-phenyldiazenyl)phenyl]-
5-(4-methoxy-phenoxy)-1H-indazole
Imidazo[1,2-a]pyrazine-8-carbaldehyde
1-Allyl-3,5-dimethyl-1H-pyrazol-4-amine
5-amino-2,3-dihydro-1H-pyrrol-2-one
Perphenazine trihydrochloride

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.