2-Methyl-2-propanyl 1-pyrrolidinecarboxylate

Names

[ CAS No. ]:
86953-79-9

[ Name ]:
2-Methyl-2-propanyl 1-pyrrolidinecarboxylate

[Synonym ]:
tert-butyl pyrrolidine-1-carboxylate
MFCD00216581

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
221.4±9.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₇NO₂

[ Molecular Weight ]:
171.237

[ Flash Point ]:
87.7±18.7 °C

[ Exact Mass ]:
171.125931

[ PSA ]:
29.54000

[ LogP ]:
1.49

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.473

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NA 1993 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Pyrrolidine
Di-tert-butyl dicarbonate
N-BOC-Pyrrole
Boc-L-Proline
3-Pyrroline
Boc-NH-C4-Br
Carbonazidic acid,1,1-dimethylethyl ester
Pyrrole
1-(tert-Butoxycarbonyl)-2-pyrrolidinone
tert-butyl 2,5-dioxopyrrolidine-1-carboxylate

DownStream

Boc-GABA-OH
tert-butyl 2-methoxypyrrolidine-1-carboxylate
Boc-D-Pro-OH
Boc-L-Proline
2-(2,9,9-TriMethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-pyrrolidine
Pyrrolidine
Isobutylene
1-(tert-Butoxycarbonyl)-2-pyrrolidinone
tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate
1-Pyrrolidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1,1-dimethylethyl ester, (2S)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications.

J. Org. Chem. 76(15) , 5936-53, (2011)

A comprehensive study of the enantioselective Pd-catalyzed α-arylation of N-Boc pyrrolidine has been carried out. The protocol involves deprotonation of N-Boc pyrrolidine using s-BuLi/(-)-sparteine in...

Asymmetric synthesis of enantioenriched (+)-elaeokanine A.

J. Org. Chem. 71(15) , 5674-8, (2006)

The key transformation in the total synthesis of (+)-elaeokanine A was accomplished by asymmetric deprotonation of N-Boc pyrrolidine, followed by the reaction of the in situ generated enantioenriched ...

Enantioselective, palladium-catalyzed α-arylation of N-boc-pyrrolidine. Campos KR, et al.

J. Am. Chem. Soc. 128(11) , 3538-3539, (2006)

2-Methyl-2-propanyl 3-(methoxymethyl)-1-pyrrolidinecarboxylate
2-Methyl-2-propanyl 3-(methylamino)-1-pyrrolidinecarboxylate hydrochloride (1:1)
2-Methyl-2-propanyl 3-(methylsulfonyl)-1-pyrrolidinecarboxylate
2-Methyl-2-propanyl 3-methyl-1-pyrrolidinecarboxylate
2-Methyl-2-propanyl 3-(cyanoacetyl)-1-pyrrolidinecarboxylate
2-Methyl-2-propanyl 3-(trifluoromethoxy)-1-pyrrolidinecarboxylate
(5-Propylthiophen-2-yl)methanesulfonyl fluoride
(3-Methanesulfonyl-2-oxopropyl)(methyl)amine
Ethyl 3-{[(benzyloxy)carbonyl]amino}-3-(5-bromo-2-fluorophenyl)propanoate
benzyl 2-(4-bromophenyl)-3,4-dihydro-2H-1,4-benzoxazine-4-carboxylate
(9H-fluoren-9-yl)methyl 3-(3-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate
3-(2,5-Dibromothiophen-3-yl)-2-(2,2,2-trifluoroacetamido)propanoic acid
Benzyl 5,8-dibromo-1,2,3,4-tetrahydroquinoline-1-carboxylate
benzyl N-(2,3,5,6-tetrafluoro-4-iodophenyl)carbamate
Tert-butyl 3-(2,6-difluoro-4-iodophenyl)morpholine-4-carboxylate
Methyl 2-{[(benzyloxy)carbonyl]amino}-2-(3-iodophenyl)acetate

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