Ulixertinib (BVD-523)

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Names

[ CAS No. ]:
869886-67-9

[ Name ]:
Ulixertinib (BVD-523)

[Synonym ]:
4-[5-Chloro-2-(isopropylamino)-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1-(3-chlorophenyl)-2-hydroxyethyl]amide
1H-Pyrrole-2-carboxamide, 4-[5-chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-
ulixertinib
VRT752271
BVD-523

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
682.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H22Cl2N4O2

[ Molecular Weight ]:
433.331

[ Flash Point ]:
366.8±31.5 °C

[ Exact Mass ]:
432.111969

[ PSA ]:
90.04000

[ LogP ]:
5.16

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.650

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (2S)-2-Amino-2-(3-chlorophenyl)ethanol
  • 4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid
  • Benzeneethanol, β-amino-3-chloro-, hydrochloride (1:1), (βS)-

DownStream

Related Compounds

  • Ulixertinib hydrochloride
  • SGX523
  • Copper, 4,4'-[azoxybis[(2-methoxy-4,1-phenylene)azo(8-hydroxy-6-sulfo-7,2-naphthalenediyl)imino]]bis[benzoate] complexes
  • Nonanoic acid, 2-[4-[1-methyl-1-[4-[2-[(1-oxo-2-propenyl)oxy]ethoxy]phenyl]ethyl]phenoxy]ethyl ester, branched
  • 2-hydroxy-N,N,N-trimethyl-3-[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)thio]propan-1-aminium chloride
  • Sovleplenib