2-Chloro-6-methylaniline

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Names

[ CAS No. ]:
87-63-8

[ Name ]:
2-Chloro-6-methylaniline

[Synonym ]:
Benzenamine, 2-chloro-6-methyl-
6-Chloro-o-toluidine
2-Amino-3-chlorotoluene
1-amino-2-methyl-6-chlorobenzene
o-Toluidine,6-chloro
6-chloro-ortho-toluidine
6-Chloro-2-toluidine
6-CHLORO-2-METHYLANILINE
MFCD00007679
Benzenamine,2-chloro-6-methyl
2-methyl-6-chloroaniline
1-Amino-2-chloro-6-methylbenzene
3-Chloro-2-aminotoluene
EINECS 201-759-2
2-Chloro-6-methylaniline
2-Chloro-6-Methylaninile
2-chloro-6-methyl-aniline
2-chloro-6-methylbenzenamine
Rivaroxaban Impurity 50

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
215.0±0.0 °C at 760 mmHg

[ Melting Point ]:
10-12 °C(lit.)

[ Molecular Formula ]:
C7H8ClN

[ Molecular Weight ]:
141.598

[ Flash Point ]:
98.9±0.0 °C

[ Exact Mass ]:
141.034531

[ PSA ]:
26.02000

[ LogP ]:
2.37

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Water Solubility ]:
Immiscible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XU5100000
CHEMICAL NAME :
o-Toluidine, 6-chloro-
CAS REGISTRY NUMBER :
87-63-8
BEILSTEIN REFERENCE NO. :
0774624
LAST UPDATED :
199707
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C7-H8-Cl-N
MOLECULAR WEIGHT :
141.61
WISWESSER LINE NOTATION :
ZR BG F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39

[ RIDADR ]:
UN 3429 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
XU5100000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzenesulfonic acid,4-amino-3-chloro-5-methyl-
  • 2'-CHLORO-2,2-DIMETHYLPROPIONANILIDE
  • 2-Chloroaniline
  • 2-Methylphenyl azide
  • N-hydroxy-2-toluidine
  • Sulfuric acid
  • Hydrochloric acid
  • Ethanol
  • 2-Nitrotoluene

DownStream

  • 7-chloro-1H-indazole
  • 3-Chloro-2-nitrobenzoic acid
  • Butanilicaine hydrochloride
  • 3-Chloro-2-nitrotoluene
  • N-(2-Chloro-6-methyl-phenyl)-3-oxo-butyramide
  • 2-Chloro-6-(trifluoromethyl)aniline
  • 2-CHLORO-6-METHYLPHENYL ISOCYANATE
  • 2-CHLORO-6-METHYLACETANILINE
  • 2-chloro-6-methylbenzenethiol
  • Butanoic acid,3-[2-(aminothioxomethyl)hydrazinylidene]-2-[2-(2-chloro-6-methylphenyl)hydrazinylidene]-,ethyl ester

Customs

[ HS Code ]: 2921430090

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

  • N-aceto-2-chloro-6-methylaniline
  • 4-Bromo-2-chloro-6-methylaniline
  • 4-t-butyl-2-chloro-6-methylaniline
  • 4-(aminomethyl)-2-chloro-6-methylaniline
  • 2-chloro-6-iodo-4-methylaniline
  • 2-Chloro-6-fluoro-3-methylaniline
  • [(3R)-4-(3-methylbutyl)morpholin-3-yl]methanamine
  • 3-[(2R)-2-(aminomethyl)pyrrolidin-1-yl]propanoic acid
  • 4-Amino-2-(3-hydroxy-2,2-dimethylpropyl)-1,2-oxazolidin-3-one
  • 6-(3-Bromophenyl)-7-hydroxy-4-oxaspiro[2.4]hept-6-en-5-one
  • 5-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-2-hydroxybenzoic acid
  • 4-{[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]methyl}benzoic acid
  • 2-cyclopropyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanamido]propanoic acid
  • 4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-{[4-(methylsulfanyl)butan-2-yl]carbamoyl}butanoic acid
  • 4-{[3-(dimethylamino)propyl]carbamoyl}-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
  • 1-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]-2-methylpyrrolidine-2-carboxylic acid
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