Leptomycin A

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Names

[ CAS No. ]:
87081-36-5

[ Name ]:
Leptomycin A

[Synonym ]:
(2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo
C32H46O6
2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo
Leptomycin A
Jildamycin

Chemical & Physical Properties

[ Density]:
1.079g/cm3

[ Boiling Point ]:
717.7ºC at 760 mmHg

[ Molecular Formula ]:
C32H46O6

[ Molecular Weight ]:
526.70400

[ Flash Point ]:
224.2ºC

[ Exact Mass ]:
526.32900

[ PSA ]:
100.90000

[ LogP ]:
6.39460

[ Index of Refraction ]:
1.544

[ Storage condition ]:
?20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RA5391000
CHEMICAL NAME :
2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)- 3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-
CAS REGISTRY NUMBER :
87081-36-5
LAST UPDATED :
199401
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C32-H46-O6
MOLECULAR WEIGHT :
526.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Yeast - Schizosaccharomyces pombe
DOSE/DURATION :
10 ug/L
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1573,1985

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
16-36/37-45

[ RIDADR ]:
UN 1230 3/PG 2

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