(R)-(-)-Etodolac

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Names

[ CAS No. ]:
87226-41-3

[ Name ]:
(R)-(-)-Etodolac

[Synonym ]:
(S)-ethyl-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido-[1,2,3-de]-1,4-benzoxazine-6-carboxylate
(-)-ethyl-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido [1,2,3-de]-1,4-benzoxazine-6-carboxylate
(R)-etodolac
(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
(R)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
R-(-)-etodolic acid
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester
ethyl (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate
[14C]-(R)-Etodolac
(-)-etodolac

Chemical & Physical Properties

[ Density]:
1.165g/cm3

[ Boiling Point ]:
452.6ºC at 760 mmHg

[ Molecular Formula ]:
C17H21NO3

[ Molecular Weight ]:
287.35400

[ Flash Point ]:
227.5ºC

[ Exact Mass ]:
287.15200

[ PSA ]:
62.32000

[ LogP ]:
3.38300

[ Index of Refraction ]:
1.581

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ0360010
CHEMICAL NAME :
Pyrano(3,4-b)indole-1-acetic acid, 1,3,4,9-tetrahydro-1,8-diethyl-, (R)-
CAS REGISTRY NUMBER :
87226-41-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H21-N-O3
MOLECULAR WEIGHT :
287.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
327 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 40,737,1990

Precursor & DownStream

Precursor

DownStream

  • Etodolac
  • 2-[(1R)-1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl]ethanol

Related Compounds

  • (R)-(-)-Etodolac-d3
  • (R)-etodolac
  • (R)-Etodolac-D4
  • (R)-(+)-S-methyl tert-butylphenylphosphinothiolate
  • ((R)-6-benzylamino-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid tert-butyl ester
  • (R-(R*,R*))-N-(2-Hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-2-o xoacetamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 4-(2-Tert-butylphenyl)butan-2-one
  • 3-[(4-Ethoxyphenyl)amino]-2-nitro-2-propenal
  • 1-(2-Amino-5-bromophenyl)pyrrolidin-2-one
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • [1-(2,6-Dimethoxy-4-methylphenyl)cyclobutyl]methanol
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(4-amino-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methyl acetate