Omecamtiv mecarbil (CK-1827452)

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Names

[ CAS No. ]:
873697-71-3

[ Name ]:
Omecamtiv mecarbil (CK-1827452)

[Synonym ]:
methyl 4-(2-fluoro-5-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate
omecamtiv mecarbil
1-Piperazinecarboxylic acid, 4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-, methyl ester
CK 1827452
Methyl 4-(2-fluoro-3-{[(6-methyl-3-pyridinyl)carbamoyl]amino}benzyl)-1-piperazinecarboxylate
methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate
S2623_Selleck
methyl 4-[(2-fluoro-3-{[(6-methyl(3-pyridyl))amino]carbonylamino}phenyl)methyl]piperazinecarboxylate
Methyl 4-[[2-fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
456.8±45.0 °C at 760 mmHg

[ Melting Point ]:
180℃

[ Molecular Formula ]:
C20H24FN5O3

[ Molecular Weight ]:
401.435

[ Flash Point ]:
230.1±28.7 °C

[ Exact Mass ]:
401.186310

[ PSA ]:
90.29000

[ LogP ]:
1.36

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.639

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-isocyanato-2-methylpyridine
  • methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate
  • 5-Bromo-2-picoline
  • (2-methylpyridin-5-yl)urea
  • methyl 4-(3-chloro-2-fluorobenzyl)piperazine-1-carboxylate
  • Methyl 1-piperazinecarboxylate

DownStream

Related Compounds

  • 1-(1-adamantyl)-3-[N'-[3-[4-[3-[[(1-adamantylcarbamoylamino)-aminomethylidene]amino]propyl]piperazin-1-yl]propyl]carbamimidoyl]urea,methanesulfonic acid
  • Aficamten
  • Semaxanib (SU5416)
  • Arp2/3 Complex Inhibitor I, Inactive Control, CK-689-CAS 170930-46-8-Calbiochem
  • Dansyl-Glu-Gly-Arg-chloromethylketone
  • 1-(4-Chlorobenzyl)piperazine