p-toluoyl chloride

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Names

[ CAS No. ]:
874-60-2

[ Name ]:
p-toluoyl chloride

[Synonym ]:
p-toluoyl chloride
p-Methylbenzoyl chloride
4-Methylbenzoyl chloride
4-Toluoyl chloride
Benzoyl chloride,4-methyl
4-Methylbenzoic acid chloride
p-Toluic acid chloride
p-Methyl-benzoylchloride
EINECS 212-864-8
MFCD00000696
4-methylbenzoic chloride
p-Toluyl chloride
4-methyl-benzoyl chloride
Benzoyl chloride, 4-methyl-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
226.0±0.0 °C at 760 mmHg

[ Melting Point ]:
−4-−2 °C(lit.)

[ Molecular Formula ]:
C8H7ClO

[ Molecular Weight ]:
154.594

[ Flash Point ]:
82.2±0.0 °C

[ Exact Mass ]:
154.018539

[ PSA ]:
17.07000

[ LogP ]:
2.67

[ Vapour density ]:
5.33 (vs air)

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.538

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XV1660000
CHEMICAL NAME :
p-Toluoyl chloride
CAS REGISTRY NUMBER :
874-60-2
BEILSTEIN REFERENCE NO. :
0471492
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H7-Cl-O
MOLECULAR WEIGHT :
154.60
WISWESSER LINE NOTATION :
GVR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04246 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8312 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
XV1660000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Methylbenzoic acid
  • carbon monoxide
  • 4-Iodotoluene
  • (4-METHYLPHENYL)-1,2-ETHANEDIOL
  • 2-(4,5-dihydro-1,3-oxazol-2-yl)aniline
  • Pyridine
  • p-Toluidine
  • p-Tolunitrile
  • O-Toluoylchloride
  • Benzotrichloride

DownStream

  • [(4-methylbenzoyl)amino] N,N-diethylcarbamodithioate
  • [4-(bromomethyl)phenyl]-(4-methylphenyl)methanone
  • 4-(4-chlorophenyl)-2-(4-methylphenyl)-4H-1,3-oxazol-5-one
  • 2-Hydroxy-4-methylbenzoic acid
  • Methyl 4-(chloromethyl)benzoate
  • 5-(4-methylphenyl)-1 3 4-oxadiazole-2-&
  • Benzenemethanol,4-methyl-a,a-bis(4-methylphenyl)-
  • 4-Cyanophenyl 4'-methylbenzoate
  • 4-Methylpropiophenone
  • Perfluorohexane

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Antigens which detect IgE antibodies in workers sensitive to toluene diisocyanate.

Clin. Allergy 10(1) , 101-9, (1980)

Two antigens, both containing tolyl groups, were compared for ability to detect IgE antibodies in workers hypersensitive to toluene diisocyanate. One antigen, formed by reaction of p-tolyl isocyanate ...

Pyrazolone incorporating bipyridyl metallointercalators as effective DNA, protein and lung cancer targets: Synthesis, characterization and in vitro biocidal evaluation.

Chem. Biol. Interact. 240 , 250-66, (2015)

Pyrazolone based metal complexes have strong bio-activity but the anti-cancer mechanism of these derivatives is not fully understood. In recent years, Cu(II) complexes have attracted the interest of r...

Benzoylation of toluene with p-toluoyl chloride over triflic acid functionalized mesoporous Zr-TMS catalyst. Landge SM, et al.

J. Mol. Catal. A: Chem. 213(2) , 257-266, (2004)


More Articles

Related Compounds

  • p-toluoyl chloride
  • 3-Nitro-p-toluoyl chloride
  • 3-chlor-p-toluoyl chloride
  • a,a-Dichloro-p-toluoyl chloride
  • 3,5-dichloro-p-toluoyl chloride
  • 3,5-dichloro-p-toluoyl chloride
  • Ethyl 8-chloro-6-fluorochromane-3-carboxylate
  • 2-(1-Bromo-2-oxopropyl)-5-(trifluoromethylthio)mandelic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2,3,5,6-Tetrafluoro-4-iodobenzoyl chloride