Thiocolchicine analog
Suppliers
Names
[ CAS No. ]:
87424-26-8
[ Name ]:
Thiocolchicine analog
[Synonym ]:
N-((S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
N-((S)-2-Hydroxy-1,3-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid
2-Demethyl Thiocolchicine
COLCHICINE,O(sup 2)-DEMETHYL-10-THIO
(S)-7-Acetylamino-2-hydroxy-1,3-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on
O(sup 2)-Demethyl-10-thiocolchicine
Chemical & Physical Properties
[ Density]:
1.33g/cm3
[ Boiling Point ]:
766.8ºC at 760 mmHg
[ Melting Point ]:
218-220ºC
[ Molecular Formula ]:
C21H23NO5S
[ Molecular Weight ]:
401.47600
[ Flash Point ]:
417.6ºC
[ Exact Mass ]:
401.13000
[ PSA ]:
110.16000
[ LogP ]:
3.67280
[ Index of Refraction ]:
1.636
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0882000
- CHEMICAL NAME :
- Colchicine, O(sup 2)-demethyl-10-thio-
- CAS REGISTRY NUMBER :
- 87424-26-8
- BEILSTEIN REFERENCE NO. :
- 3176298
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C21-H23-N-O5-S
- MOLECULAR WEIGHT :
- 401.51
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957