4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2- methanol

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Names

[ CAS No. ]:
875548-97-3

[ Name ]:
4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2- methanol

[Synonym ]:
4'-FLUORO-2'-METHOXY-5'-ISOPROPYL-4-TRIFLUOROMETHYL-1,1'-BIPHENYL-2-METHANOL
(4'-FLUORO-5'-ISOPROPYL-2'-METHOXY-4-TRIFLUOROMETHYL-BIPHENYL-2-YL)METHANOL
[4'-Fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-2-biphenylyl]methanol
[1,1'-Biphenyl]-2-methanol, 4'-fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)-
[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methanol
4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2- methanol
Anacetrapib Intermediate 5

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
364.5±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H18F4O2

[ Molecular Weight ]:
342.328

[ Flash Point ]:
168.0±24.4 °C

[ Exact Mass ]:
342.124298

[ PSA ]:
29.46000

[ LogP ]:
4.75

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.505

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid
  • 2-Chloro-5-(trifluoromethyl)benzyl alcohol
  • 1-Bromo-4-fluoro-5-isopropyl-2-methoxybenzene
  • 2-Bromo-5-(trifluoromethyl)benzyl alcohol
  • [2-Iodo-5-(trifluoromethyl)phenyl]methanol
  • 2-(Bromomethyl)-1-iodo-4-(trifluoromethyl)benzene
  • methyl 4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxylate
  • 2'-Fluoro-4'-methoxyacetophenone

DownStream

  • Anacetrapib

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 4,6-Dimethyl-2-{3-[(pyrazin-2-yloxy)methyl]piperidin-1-yl}pyridine-3-carbonitrile
  • 3-[[(4S)-4,5-Dihydro-2-methyl-4-oxazolyl]methyl]-1-phenyl-1H-indole
  • 1-[2-(Pyrrolidin-1-yl)pyridin-3-yl]cyclopentan-1-amine
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • {2-[(1,2,3,4-Tetrahydronaphthalen-1-yl)amino]pyrimidin-4-yl}methanol
  • 1-(2,6-Difluoro-3-methylphenyl)-2,2-difluorocyclopropane-1-carboxylic acid