N-BOC-cis-4-Hydroxy-L-proline

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Names

[ CAS No. ]:
87691-27-8

[ Name ]:
N-BOC-cis-4-Hydroxy-L-proline

[Synonym ]:
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4S)-
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4R)-
(4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
MFCD02094406
Boc-(2S,4S)-(-)-4-hydroxypyrrolidine-2-carboxylic acid
(4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
390.9±42.0 °C at 760 mmHg

[ Melting Point ]:
146ºC

[ Molecular Formula ]:
C10H17NO5

[ Molecular Weight ]:
231.246

[ Flash Point ]:
190.2±27.9 °C

[ Exact Mass ]:
231.110672

[ PSA ]:
87.07000

[ LogP ]:
-0.71

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.531

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H400

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R36/37/38;R50

[ Safety Phrases ]:
S26-S36/37-S60-S61

[ RIDADR ]:
UN 3077 9 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Di-tert-butyl dicarbonate
  • cis-4-hydroxy-L-proline
  • Boc-Hyp-OMe
  • N-Boc-4-oxo-L-proline
  • tert-butyl 3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate
  • Boc-Hyp-OH
  • (2S,4S)-1-(3,3-dimethylbutoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate
  • ethyl (4S)-2-(N-tert-butyloxycarbonylamino)-5-tert-butyldimethylsiloxy-4-tert-butyldiphenylsiloxy-2-pentenoate

DownStream

  • L-Hydroxyproline
  • (2S,4S)-1-(tert-Butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid
  • N-Boc-4-oxo-L-proline
  • cis-4-hydroxy-L-proline
  • N-Boc-trans-4-amino-L-proline methyl ester
  • Boc-Hyp-OH
  • N-t-BOC-trans-4-Fluoro-L-Proline
  • (2S-trans)-4-Azido-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) 2-Methyl Ester
  • (2S,4R)-1-(tert-butoxycarbonyl)-4-(tosyloxy)pyrrolidine-2-carboxylic acid

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-Boc-cis-4-Hydroxy-L-prolinem ethylester
  • N-Boc-cis-4-Hydroxy-L-prolinem ethylester
  • N-Boc-cis-4-hydroxy-L-proline Methyl Ester
  • N-Boc-cis-4-Hydroxy-D-proline
  • N-t-Boc-cis-4-hydroxy-L-proline methyl ester
  • trans-4-hydroxy-L-proline methyl ester