3-Methoxysalicylic acid

Names

[ CAS No. ]:
877-22-5

[ Name ]:
3-Methoxysalicylic acid

[Synonym ]:
2-Hydroxy-3-methoxybenzoic acid
Benzoic acid, 2-hydroxy-3-methoxy-
3-Methoxysalicylic acid
EINECS 212-888-9
MFCD07371432

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
315.7±27.0 °C at 760 mmHg

[ Melting Point ]:
147-150 °C(lit.)

[ Molecular Formula ]:
C₈H₈O₄

[ Molecular Weight ]:
168.147

[ Flash Point ]:
131.6±17.2 °C

[ Exact Mass ]:
168.042252

[ PSA ]:
66.76000

[ LogP ]:
1.98

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.586

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ4840000

CHEMICAL NAME :: m-Anisic acid, 2-hydroxy-

CAS REGISTRY NUMBER :: 877-22-5

BEILSTEIN REFERENCE NO. :: 2209642

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H8-O4

MOLECULAR WEIGHT :: 168.16

WISWESSER LINE NOTATION :: QVR BQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2056 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 243,609,1956

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BZ4840000

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-Methoxysalicylaldehyde
2,3-Dimethoxybenzoic acid
3-Methoxybenzoic acid
2-Hydroxymethyl-6-methoxy-phenol
Potassium hydrogen carbonate
Guaiacol
Carbon dioxide
sodium 2-methoxyphenolate

DownStream

4-Nitroguaiacol
Carbon dioxide
Guaiacol
2-ACETOXY-3-METHOXYBENZOIC ACID
(2,5-dioxopyrrolidin-1-yl) 2,3-dihydroxy-5-nitrobenzoate
Methyl 5-allyl-2-hydroxy-3-methoxybenzoate
Pimelic acid
Eugenol
2,3-Dihydroxybenzoic acid
2-Methoxy-6-allylphenol

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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