2-Nitrochlorobenzene

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Names

[ CAS No. ]:
88-73-3

[ Name ]:
2-Nitrochlorobenzene

[Synonym ]:
2-Nitrochlorobenzene
1-Chloro-2-nitro-benzene
ortho-chloronitrobenzene
1-Nitro-2-chlorobenzene
benzene, chloronitro-
chloronitrobenzene
MFCD00007061
EINECS 201-854-9
nitrochlorobenzene
Nitrochlorobenzene, o-
o-chloronitrobenzene
o-Nitrochlorobenzene
Benzene, 1-chloro-2-nitro-
2-CHLORO-1-NITROBENZENE
1-chloronitrobenzene
Nitrochlorobenzene, ortho
1-Chloro-2-nitrobenzene
2-Chloronitrobenzene

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
245.5±0.0 °C at 760 mmHg

[ Melting Point ]:
31-33 °C(lit.)

[ Molecular Formula ]:
C6H4ClNO2

[ Molecular Weight ]:
157.555

[ Flash Point ]:
96.5±19.8 °C

[ Exact Mass ]:
156.993057

[ PSA ]:
45.82000

[ LogP ]:
2.34

[ Vapour density ]:
5.4 (vs air)

[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, strong bases, alkali metals.

[ Water Solubility ]:
0.43 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ0875000
CHEMICAL NAME :
Benzene, 1-chloro-2-nitro-
CAS REGISTRY NUMBER :
88-73-3
LAST UPDATED :
199712
DATA ITEMS CITED :
26
MOLECULAR FORMULA :
C6-H4-Cl-N-O2
MOLECULAR WEIGHT :
157.56
WISWESSER LINE NOTATION :
WNR BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
268 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/m3/6H/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4500 ppb/6H/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 ppm/6H/2W-C
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2300 ppb/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Endocrine - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
18 ppm/6H
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
4500 ppb/6H
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl 1),3,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4011 No. of Facilities: 42 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2897 (estimated) No. of Female Employees: 662 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311

[ Precautionary Statements ]:
P280-P301 + P310-P312

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R22;R24;R52/53

[ Safety Phrases ]:
S36/37/39-S45-S60-S38-S28A

[ RIDADR ]:
UN 1578 6.1/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
CZ0875000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29049085

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Bromo-2-nitrobenzene
  • 2-Chloroaniline
  • 2-Nitroaniline
  • Chlorobenzene
  • 2-Nitrobenzoic acid
  • 4-Chloronitrobenzene
  • Anilinium chloride
  • o-Nitrophenylsulfonyl chloride
  • Anisole
  • nitrobenzene

DownStream

  • 2-chlorophenylhydroxylamine
  • 2-Chloroaniline
  • 1,2-Bis(2-chlorophenyl)hydrazine
  • Diazene,1,2-bis(2-chlorophenyl)-, 1-oxide
  • Diethyl (2-nitrophenyl)malonate
  • 1-(2-NITRO-PHENYL)-3-PHENYL-PIPERAZINE
  • clemizole
  • Benzenamine,N-(4-methoxyphenyl)-2-nitro-
  • 2-(o-Tolyloxy)-aniline

Customs

[ HS Code ]: 2904901100

[ Summary ]:
2904901100 1-chloro-2-nitrobenzene. Supervision conditions:None.VAT:17.0% Tax rebate rate:9.0%

Articles

Dinitrochlorobenzene is inherently mutagenic in the presence of trace mutagenic contaminants.

Arch. Dermatol. 124(3) , 396-8, (1988)

2,4-Dinitrochlorobenzene (DNCB) is used for immunotherapy of alopecia areata and verruca vulgaris. We initially postulated that the presence of mutagenic contaminants in commercially available DNCB mi...

Determination of trace level genotoxic impurities in small molecule drug substances using conventional headspace gas chromatography with contemporary ionic liquid diluents and electron capture detection.

J. Chromatogr. A. 1361 , 217-28, (2014)

Ionic liquids (ILs) were used as a new class of diluents for the analysis of two classes of genotoxic impurities (GTIs), namely, alkyl/aryl halides and nitro-aromatics, in small molecule drug substanc...

2-Chloronitrobenzene, 3-chloronitrobenzene and 4-chloronitrobenzene.

IARC Monogr. Eval. Carcinog. Risks Hum. 65 , 263-96, (1996)


More Articles

Related Compounds

  • 4-sulfo-2-nitrochlorobenzene
  • 4-methyl-2-nitrochlorobenzene
  • 4-methyl-2-nitrochlorobenzene
  • 4-methoxy-2-nitrochlorobenzene
  • 4-n-butanoyl-2-nitrochlorobenzene
  • 4-chloromethylsulfonyl-2-nitrochlorobenzene
  • (S,Z)-1-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)but-2-yn-1-one O-morpholin-3-ylmethyl oxime
  • 2-cyclohexyl-1-(4-(3-(3-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)ethanone
  • 1-(adamantane-1-carbonyl)-4-[3-(3-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]piperazine
  • 2-chloro-1-(4-(3-(3-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)ethanone
  • N-(5-(1-isopropyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropanamide
  • 3-chloro-1-(4-(3-(3-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)propan-1-one
  • 3-chloro-1-(4-(3-(3-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)-2,2-dimethylpropan-1-one
  • (4-(3-(3-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)(phenyl)methanone
  • (4-(3-(3-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)(o-tolyl)methanone
  • (4-(3-(3-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)(p-tolyl)methanone
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