Benzene,1,3-bis(trichloromethyl)-

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Names

[ CAS No. ]:
881-99-2

[ Name ]:
Benzene,1,3-bis(trichloromethyl)-

[Synonym ]:
EINECS 212-923-8
α,α,α,α',α',α'-HEXACHLORO-M-XYLENE
MFCD00018821

Chemical & Physical Properties

[ Density]:
1.628g/cm3

[ Boiling Point ]:
305.8ºC at 760 mmHg

[ Molecular Formula ]:
C8H4Cl6

[ Molecular Weight ]:
312.83500

[ Flash Point ]:
38 °C

[ Exact Mass ]:
309.84400

[ LogP ]:
5.34000

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZE4650000
CHEMICAL NAME :
m-Xylene, alpha,alpha,alpha,alpha',alpha',alpha'-hexachloro-
CAS REGISTRY NUMBER :
881-99-2
BEILSTEIN REFERENCE NO. :
2214335
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C8-H4-Cl6
MOLECULAR WEIGHT :
312.82
WISWESSER LINE NOTATION :
GXGGR CXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,308,1969 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2924 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5700 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(11),51,1985 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2129 mg/kg
SEX/DURATION :
male 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2129 mg/kg
SEX/DURATION :
female 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982

Safety Information

[ Risk Phrases ]:
20/21/22-36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
2810

[ RTECS ]:
ZE4650000

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • α,α,α',α'-Tetrachloro-m-xylene
  • m-Xylene
  • Chlorine

DownStream

  • 1-Fluoro-3,5-bis(trifluoromethyl)benzene
  • 1-Chloro-3,5-bis(trifluoromethyl)benzene
  • 1,3-Bis(trifluoromethyl)benzene
  • 5-chloroisophthalic acid
  • 1,3-Bis[(2H3)methyl]benzene
  • m-phthaloyl chloride
  • chlorophenylsulfone
  • 3-trifluoromethyl benzotrichloride
  • 3-(Trichloromethyl)benzoyl chloride
  • 1-chloro-3,5-bis(trichloromethyl)benzene

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Related Compounds

  • Benzene,1,3-bis(trimethylsilyl)-
  • Benzene, 1,3-bis(3-(3-phenoxyphenoxy)phenoxy)-
  • Benzene,1,3-bis(isothiocyanatomethyl)-
  • Benzene,1,3-bis(2,4-dinitrophenoxy)-
  • Benzene,1,3-bis(3-bromopropoxy)-
  • Benzene, 1,3-bis(chloromethyl)-2,4,6-trifluoro-5-(trifluoromethyl)
  • tert-Butyl (R)-2-methyl-4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazine-1-carboxylate
  • 4-(1-Amino-3-hydroxycyclobutyl)-2-fluorophenol
  • 2-Chloro-4-(2-methylprop-1-en-1-yl)benzonitrile
  • Ethyl 4-(2,2,2-trifluoroethyl)thiazole-2-carboxylate
  • (4-(2,2,2-Trifluoroethyl)thiazol-2-yl)methanol
  • 5-bromo-6-(difluoromethoxy)-2-Pyridinemethanol
  • 2-((3R,5S)-4,4-Difluoro-5-methylpiperidin-3-yl)ethan-1-ol
  • 3-Chloro-4-(1-methylethyl)-2-pyridinecarbonitrile
  • tert-Butyl (4-fluoro-4-(hydroxymethyl)piperidin-1-yl)carbamate
  • 5-Bromo-7-fluoro-1H-indol-3-amine hydrochloride