5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
Suppliers
Names
[ CAS No. ]:
88254-07-3
[ Name ]:
5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
[Synonym ]:
5,12-Naphthacenedione, 10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-.α.- L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
MRA-CN
3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin
cyanomorpholino-doxorubicin
3'-Deamino-3'-(3-cyano-4-morpholinyl)adriamycin
Chemical & Physical Properties
[ Density]:
1.59g/cm3
[ Boiling Point ]:
899.2ºC at 760 mmHg
[ Molecular Formula ]:
C32H34N2O12
[ Molecular Weight ]:
638.61900
[ Flash Point ]:
497.6ºC
[ Exact Mass ]:
638.21100
[ PSA ]:
216.31000
[ LogP ]:
0.20488
[ Index of Refraction ]:
1.697
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9405000
- CHEMICAL NAME :
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-(3-cyanomorpholino)-2,3,6- trideoxy- alpha-L-lyxo-hexopyranosyl)oxy)-8-(hydroxyacetyl)-1-m ethoxy-6,8,11-trihydr oxy-, (8s-cis)-
- CAS REGISTRY NUMBER :
- 88254-07-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C32-H34-N2-O12
- MOLECULAR WEIGHT :
- 638.68
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 30 ng/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,5599,1984