5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-

Suppliers

Names

[ CAS No. ]:
88254-07-3

[ Name ]:
5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-

[Synonym ]:
5,12-Naphthacenedione, 10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-.α.- L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
MRA-CN
3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin
cyanomorpholino-doxorubicin
3'-Deamino-3'-(3-cyano-4-morpholinyl)adriamycin

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Boiling Point ]:
899.2ºC at 760 mmHg

[ Molecular Formula ]:
C32H34N2O12

[ Molecular Weight ]:
638.61900

[ Flash Point ]:
497.6ºC

[ Exact Mass ]:
638.21100

[ PSA ]:
216.31000

[ LogP ]:
0.20488

[ Index of Refraction ]:
1.697

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QI9405000
CHEMICAL NAME :
5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-(3-cyanomorpholino)-2,3,6- trideoxy- alpha-L-lyxo-hexopyranosyl)oxy)-8-(hydroxyacetyl)-1-m ethoxy-6,8,11-trihydr oxy-, (8s-cis)-
CAS REGISTRY NUMBER :
88254-07-3
LAST UPDATED :
199612
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C32-H34-N2-O12
MOLECULAR WEIGHT :
638.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
30 ng/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,5599,1984

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(2-oxoethoxy)acetaldehyde
  • Doxorubicin Hydrochloride
  • Acetonitrile

DownStream

Related Compounds

  • 1-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethan-1-one
  • 2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-ol
  • {2-[5-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-3,4-dihydro-2H-[1,7]naphthyridin-1-yl]-ethyl}-carbamic acid tert-butyl ester
  • ((3aR,4R,6S,6aS)-6-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
  • 4-Methyl-6-prop-1-enylpyridin-2-amine
  • N-((2s,3r)-1-(4-Fluorophenyl)-3-Hydroxy-4-((6'-Neopentyl-3',4'-Dihydrospiro[cyclobutane-1,2'-Pyrano[2,3-B]pyridin]-4'-Yl)amino)butan-2-Yl)acetamide
  • 3-Methoxy-4-(methylsulfinyl)benzenamine
  • 3-Methyl-5-(1-(4-(methylthio)benzyl)azetidin-3-yl)-1,2,4-oxadiazole oxalate
  • 3-Methyl-5-(1-(thiophen-3-ylmethyl)azetidin-3-yl)-1,2,4-oxadiazole oxalate
  • 5-(1-((4-Bromothiophen-2-yl)methyl)azetidin-3-yl)-3-methyl-1,2,4-oxadiazole oxalate
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