Dibenz[cd,g]indazol-6(2H)-one,7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-,hydrochloride (1:2)

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Names

[ CAS No. ]:
88303-61-1

[ Name ]:
Dibenz[cd,g]indazol-6(2H)-one,7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-,hydrochloride (1:2)

[Synonym ]:
Biantrazole
Biantrazole dihydrochloride
CI 941
DuP-941
Bianthrazole dihydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
840.3ºC at 760 mmHg

[ Molecular Formula ]:
C22H28ClN5O4

[ Molecular Weight ]:
461.94200

[ Flash Point ]:
462ºC

[ Exact Mass ]:
461.18300

[ PSA ]:
131.67000

[ LogP ]:
2.07880

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB4594000
CHEMICAL NAME :
Anthra(1,9-cd)pyrazol-6(2H)-one, 7-hydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(( 2- hydroxyethyl)amino)ethyl)amino)-, dihydrochloride
CAS REGISTRY NUMBER :
88303-61-1
LAST UPDATED :
199410
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H27-N5-O4.2Cl-H
MOLECULAR WEIGHT :
498.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 23,8,1989

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-2-[2-[(2-hydroxyethyl)(phenylmethyl)amino]ethyl]-7-(phenylmethoxy)anthra[1,9-cd]pyrazol-6(2H)-one
  • Losoxantrone
  • 5-chloro-2-[2-[(2-hydroxyethyl)amino]ethyl]-7-hydroxyanthra[1,9-cd]pyrazol-6(2H)-one
  • 2-(2-Aminoethylamino)ethanol
  • 1,4-dichloro-5-hydroxyanthracene-9,10-dione
  • 1,4-dichloro-5-(phenylmethoxy)-9,10-anthracenedione
  • 5-chloro-2-[2-[(2-hydroxyethyl)(phenylmethyl)amino]ethyl]-7-(phenylmethoxy)anthra[1,9-cd]pyrazol-6(2H)-one

DownStream

Related Compounds

  • N-[1-(4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridin-2-yl)ethyl]prop-2-enamide
  • 1-[2-(2-Methylpyrazol-3-yl)piperidin-1-yl]prop-2-en-1-one
  • N-(5-Cyclopropyl-1-propan-2-ylpyrazol-4-yl)prop-2-enamide
  • N-({3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridin-1-yl}methyl)prop-2-enamide
  • n-(1-Cyclohexyl-1h-pyrazol-3-yl)prop-2-enamide
  • 1-[3-(1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]prop-2-en-1-one
  • N-(2,3-Dihydro-1-benzothiophen-3-ylmethyl)prop-2-enamide
  • N-((5-(Trifluoromethyl)isoxazol-3-yl)methyl)acrylamide
  • 1-[4-(Triazol-1-yl)azepan-1-yl]prop-2-en-1-one
  • 1-[4-(1,2,4-Triazol-4-ylmethyl)piperidin-1-yl]prop-2-en-1-one
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