Buparvaquone
Suppliers
Names
[ CAS No. ]:
88426-33-9
[ Name ]:
Buparvaquone
[Synonym ]:
2-[(4-tert-butylcyclohexyl)methyl]-3-hydroxynaphthalene-1,4-dione
2-[[4-(1,1-Dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione
Butalex
UNII-0354RT7LG4
1,4-Naphthalenedione, 2-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]-3-hydroxy-
2-[(4-tert-Butylcyclohexyl)methyl]-3-hydroxynaphthalen-1,4-dion
2-((4-tert-Butylcyclohexyl)methyl)-3-hydroxy-1,4-naphthochinon
BW 720C
Buparvaquone
Buparvaquonum [Latin]
Buparvacuona [Spanish]
3-(4-t-Butylcyclohexyl)methyl-2-hydroxy-1,4-naphthoquinone
MFCD01712789
2-((4-(1,1-Dimethylethyl)cyclohexyl)methyl)-3-hydroxy-1,4-naphthalenedione
2-[(4-tert-Butylcyclohexyl)methyl]-3-hydroxy-1,4-naphthoquinone
2-Hydroxy-3-{[4-(2-methyl-2-propanyl)cyclohexyl]methyl}-1,4-naphthoquinone
2-((4-tert-Butylcyclohexyl)methyl)-3-hydroxy-1,4-naphthoquinone
1,4-Naphthalenedione, 2-((4-(1,1-dimethylethyl)cyclohexyl)methyl)-3-hydroxy-
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
460.7±45.0 °C at 760 mmHg
[ Melting Point ]:
178-184ºC
[ Molecular Formula ]:
C21H26O3
[ Molecular Weight ]:
326.429
[ Flash Point ]:
246.5±25.2 °C
[ Exact Mass ]:
326.188202
[ PSA ]:
54.37000
[ LogP ]:
6.45
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.574
[ Storage condition ]:
Refrigerator
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QJ5766600
- CHEMICAL NAME :
- 1,4-Naphthalenedione, 2-((4-(1,1-dimethylethyl)cyclohexyl)methyl)-3-hydroxy -
- CAS REGISTRY NUMBER :
- 88426-33-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H26-O3
- MOLECULAR WEIGHT :
- 326.47
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PARAAE Parasitology. (Cambridge University Press, The Edinburgh Bldg., Shaftesbury Rd., Cambridge, CB2 2RU, United Kingdom) V.1- 1908- Volume(issue)/page/year: 90,45,1985
Safety Information
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
QJ5766600
Articles
Expert Opin. Drug Deliv. 9(9) , 1083-97, (2012)
The parenteral administration of pentavalent antimonials for the treatment of all forms of leishmaniasis, including cutaneous leishamniasis (CL), has several limitations. Therapy is long, requiring re...
J. Vet. Med. Sci. 65(11) , 1171-7, (2003)
The therapeutic efficacy of imidocarb, artesunate, arteether, buparvaquone and arteether+buparvaquone combination was evaluated against Babesia equi of Indian origin in splenectomised donkeys with exp...
Eur. J. Pharm. Sci. 23(2) , 151-8, (2004)
Novel water-soluble phosphate prodrugs (2b-5b) of buparvaquone-oxime (1a) and buparvaquone-O-methyloxime (1b) were synthesized and evaluated in vitro as potential oral prodrugs against leishmaniasis. ...