Togni's Reagent

Suppliers

Names

[ CAS No. ]:
887144-97-0

[ Name ]:
Togni's Reagent

[Synonym ]:
MFCD10567056
Togni's Reagent
1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
3,3-Dmethyl-1-(trifluoromethyl)-1,2-benziodoxole
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Togni's Reagent: dimethyl compound
3,3-Dimethyl-1-(trifluoromethyl)-1,3-dihydro-1λ,2-benziodoxole
UNII:3OK0E02MT6
3,3-dimethyl-1-(trifluoromethyl)-1λ<sup>3</sup>,2-benziodoxole

Chemical & Physical Properties

[ Melting Point ]:
75-79ºC

[ Molecular Formula ]:
C10H10F3IO

[ Molecular Weight ]:
330.086

[ Exact Mass ]:
329.972839

[ PSA ]:
9.23000

[ LogP ]:
4.06270

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H228-H315-H319-H335

[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
UN1325 - class 4.1 - PG 3 - Flammable solids, organic, n.o.s., HI: all

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole
  • (Trifluoromethyl)trimethylsilane
  • Methyl 2-iodobenzoate
  • 2-(2-Iodophenyl)propan-2-ol
  • 2-Iodobenzoic acid
  • Methyl 2-aminobenzoate

DownStream

  • 2-[(Trifluoromethyl)sulfanyl]aniline
  • 3-(trifluoromethyl)acetanilide
  • 2-Trifluoromethylbenzimidazole
  • 4-(Trifluoromethylthio)nitrobenzene
  • 4-Trifluoromethylpyridine
  • 3-trifluoromethylpyridine
  • 2-(Trifluoromethyl)pyridine
  • 3-((trifluoromethyl)thio)aniline
  • 2-Trifluoromethyl-1H-indole
  • 4-Chloro-2-(trifluoromethyl)aniline

Articles

A Ritter-type reaction: direct electrophilic trifluoromethylation at nitrogen atoms using hypervalent iodine reagents.

Angew. Chem. Int. Ed. Engl. 5th ed., 50 , 1059-1063, (2011)

The productive merger of iodonium salts and organocatalysis: a non-photolytic approach to the enantioselective alpha-trifluoromethylation of aldehydes.

J. Am. Chem. Soc. 132 , 4986-4987, (2010)

An enantioselective organocatalytic alpha-trifluoromethylation of aldehydes has been accomplished using a commercially available, electrophilic trifluoromethyl source. The merging of Lewis acid and or...

Pd(II)-catalyzed ortho-trifluoromethylation of arenes using TFA as a promoter.

J. Am. Chem. Soc. 11th ed., 132 , 3648-3649, (2010)

A Pd(II)-catalyzed C-H activation/trifluoromethylation of arenes with an electrophilic trifluoromethylation reagent using diverse heterocycle directing groups is reported. The presence of trifluoroace...


More Articles

Related Compounds

  • Togni's Reagent: Carbonyl compound
  • Eschenmoser's reagent
  • Comins' Reagent
  • Cornforth reagent
  • Hendrickson's reagent
  • Stang's reagent
  • 2-Methoxy-3-[5-(methoxycarbonyl)furan-2-yl]propanoic acid
  • 2-Amino-1-[2-(trifluoromethyl)pyridin-3-yl]ethan-1-ol
  • tert-butyl N-[2-hydroxy-3-methoxy-5-(3-oxobutyl)phenyl]carbamate
  • 3-Amino-1-(difluoromethyl)cyclobutane-1-carboxylic acid
  • 1-[1-(2-Cyclopropylphenyl)cyclopropyl]cyclopropan-1-amine
  • 4-(3-Aminopropoxy)-5-bromo-2-methoxyphenol
  • tert-butyl N-[4-chloro-3-(1-cyanocyclobutyl)phenyl]carbamate
  • Methyl 2-amino-2-[1-(3,4-difluorophenyl)cyclopropyl]acetate
  • tert-butyl N-[2-(4,5-difluoro-2-nitrophenyl)-1-oxopropan-2-yl]-N-methylcarbamate
  • Sodium5-(2-bromo-4-chlorophenyl)-1,3,4-thiadiazole-2-carboxylate
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