2-sec-Butylphenol

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Names

[ CAS No. ]:
89-72-5

[ Name ]:
2-sec-Butylphenol

[Synonym ]:
2-sec.Butylfenol
6-sec-butyl-phenol
O-S-BUTYLPHENOL
o-sec-butyl-pheno
2-sec.-butylphenol
2-sek.Butylphenol
Phenol,o-sec-butyl
EINECS 201-933-8
O-SEC-BUTYLPHENOL
2-sec-Butylphenol
ortho-sec-butylphenol
OSBP
MFCD00002225
methylpropylphenol

Chemical & Physical Properties

[ Density]:
0.982 g/mL at 25 °C(lit.)

[ Boiling Point ]:
226-228 °C(lit.)

[ Melting Point ]:
12 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₄O

[ Molecular Weight ]:
150.21800

[ Flash Point ]:
234 °F

[ Exact Mass ]:
150.10400

[ PSA ]:
20.23000

[ LogP ]:
2.90570

[ Vapour Pressure ]:
0.03 mm Hg ( 20 °C)

[ Index of Refraction ]:
n20/D 1.522(lit.)

[ Stability ]:
Stable, but air sensitive. Incompatible with acid chlorides, acid anhydrides, bases, strong oxidizing agents, copper and its alloys, brass.

[ Water Solubility ]:
Insoluble.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ8920000

CHEMICAL NAME :: Phenol, o-sec-butyl-

CAS REGISTRY NUMBER :: 89-72-5

BEILSTEIN REFERENCE NO. :: 1210026

LAST UPDATED :: 199712

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C10-H14-O

MOLECULAR WEIGHT :: 150.24

WISWESSER LINE NOTATION :: QR BY2&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,224,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,224,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,868,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,84,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

REFERENCE :: 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,84,1986 *** REVIEWS *** ACGIH TLV-TWA 31 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (31 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-sec-BUTYLPHENOL-air:10H TWA 5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83612 No. of Facilities: 41 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 316 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R22;R34

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3145 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
SJ8920000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2907191090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Butene
Isobutylene
Phenol
Cyclohexanol,2-(1-methylpropyl)-
Palladium
Butanol
butan-2-yloxybenzene
Butoxybenzene
Aluminum Powder
UNII:862GFQ832E

DownStream

Fenobucarb
Phenol,2,4-bis(1-methylpropyl)-
Phenol
4-(2-Butyl)phenol
dinoseb
2-sec-butyl-6-propylphenol
(2S,5R)-N-BOC-5-METHYLPYRROLIDINE-2-CARBOXYLICACID
2,5-Bis(1-methylpropyl)phenol
2,4,6-tri-sec-butylphenol
(2-butan-2-ylphenyl) N-propylcarbamate

Customs

[ HS Code ]: 2907191090

[ Summary ]:
2907191090 2-(sec-butyl)phenol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:4.0%。General tariff:11.0%

Articles

Isolation and characterization of a novel 2-sec-butylphenol-degrading bacterium Pseudomonas sp. strain MS-1.

Biodegradation 21(2) , 157-65, (2010)

A novel bacterium capable of utilizing 2-sec-butylphenol as the sole carbon and energy source, Pseudomonas sp. strain MS-1, was isolated from freshwater sediment. Within 30 h, strain MS-1 completely d...

Induction of CYP102 (cytochrome P450BM-3) in Bacillus megaterium by 17 beta-estradiol and 4-sec-butylphenol.

Biochem. Biophys. Res. Commun. 244(3) , 868-72, (1998)

CYP102 (Cytochrome P450BM-3) is induced in Bacillus megaterium by barbiturates, peroxisome proliferators, and nonsteroidal anti-inflammatory drugs. We now describe the induction of CYP102 in B. megate...

Spectrophotometric determination of nitrate in vegetable products using 2-sec-butylphenol.

Analyst 107(1271) , 190-4, (1982)