2,4-Dihydroxyacetophenone

Suppliers

Names

[ CAS No. ]:
89-84-9

[ Name ]:
2,4-Dihydroxyacetophenone

[Synonym ]:
2,4-Dihydroxyacetophenone
1-(2,4-Dihydroxyphenyl)ethanone
Ethanone, 1-(2,4-dihydroxyphenyl)-
EINECS 201-945-3
2',4'-Dihydroxyacetophenone
MFCD00002279
Acetophenone, 2',4'-dihydroxy-
Resacetophenone

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
319.3±12.0 °C at 760 mmHg

[ Melting Point ]:
143-144.5 °C(lit.)

[ Molecular Formula ]:
C8H8O3

[ Molecular Weight ]:
152.147

[ Flash Point ]:
161.1±16.1 °C

[ Exact Mass ]:
152.047348

[ PSA ]:
57.53000

[ LogP ]:
1.74

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.595

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AM7525000
CHEMICAL NAME :
Acetophenone, 2',4'-dihydroxy-
CAS REGISTRY NUMBER :
89-84-9
BEILSTEIN REFERENCE NO. :
1282505
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H8-O3
MOLECULAR WEIGHT :
152.16
WISWESSER LINE NOTATION :
QR CQ DV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
20 mg/kg
SEX/DURATION :
female 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. Volume(issue)/page/year: 19,264,1960

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
AM7525000

[ HS Code ]:
2914391000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • acetic acid
  • Resorcine
  • Acetyl chloride
  • Ethanoic anhydride
  • Benzene, 1,3-diethoxy-
  • 1-(2-hydroxy-4-prop-2-enoxyphenyl)ethanone
  • (4-acetyl-3-acetyloxyphenyl) acetate
  • Ethanone,1-(2,4-dihydroxyphenyl)-, oxime
  • 1,3-Dimethoxybenzene
  • phenyl acetate

DownStream

  • 1-[2-Hydroxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone
  • (5-acetyl-1-benzofuran-4-yl) benzoate
  • 7-(3-chloropropoxy)-4H-chroMen-4-one
  • 1-[4-(2-Chloro-Ethoxy)-2-Hydroxy-Phenyl]-Ethanone
  • Ethanone,1-(2,4-dihydroxyphenyl)-, oxime
  • 5,7-Dihydroxychromone
  • 4'-ETHOXY-2'-HYDROXYACETOPHENONE
  • 2',4'-dimethoxyacetophenone
  • 1-(2,4-DIETHOXY-PHENYL)-ETHANONE
  • Gallacetophenone

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor.

Nat. Prod. Commun. 6(8) , 1129-30, (2011)

Biotransformation of paeonol (1) with the white-rot basidiomycete Coriolus versicolor afforded two metabolites, 2,4-dihydroxyacetophenone (2) and 2,5-dihydroxy-4-methoxyacetophenone (3), which were id...

Multifaceted defense against antagonistic microbes in developing offspring of the parasitoid wasp Ampulex compressa (Hymenoptera, Ampulicidae).

PLoS ONE 9(6) , e98784, (2014)

Effective antimicrobial strategies are essential adaptations of insects to protect themselves, their offspring, and their foods from microbial pathogens and decomposers. Larvae of the emerald cockroac...

Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base.

Molecules 20 , 9788-802, (2015)

Co(II), Ni(II), Zn(II) and Cu(II) complexes of (3E)-3-[(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one (DEPH2) derived from ethylenediamine, 2',4'-dihydroxyacetopheno...


More Articles

Related Compounds

  • 5-allyl-2,4-dihydroxyacetophenone
  • 3-formyl-2,4-dihydroxyacetophenone
  • 5C-benzyl-2,4-dihydroxyacetophenone
  • 2,4-dihydroxyacetophenone semicarbazone
  • α-(1,3-benzodioxol-5-yl)-2,4-dihydroxyacetophenone
  • 2,4-dihydroxy-6-(benzyloxy)acetophenone