3-(2-Fluorophenyl)-2-(methylthio)-4(3H)-pyrimidinone

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Names

[ CAS No. ]:
89069-19-2

[ Name ]:
3-(2-Fluorophenyl)-2-(methylthio)-4(3H)-pyrimidinone

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
347.7ºC at 760 mmHg

[ Molecular Formula ]:
C11H9FN2OS

[ Molecular Weight ]:
236.26500

[ Flash Point ]:
164.1ºC

[ Exact Mass ]:
236.04200

[ PSA ]:
60.19000

[ LogP ]:
2.09350

[ Index of Refraction ]:
1.614

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW7485000
CHEMICAL NAME :
4(3H)-Pyrimidinone, 3-(2-fluorophenyl)-2-(methylthio)-
CAS REGISTRY NUMBER :
89069-19-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H9-F-N2-O-S
MOLECULAR WEIGHT :
236.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. (Publications & Information Directorate, Council of Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012, India) V.14B- 1976- Volume(issue)/page/year: 22,789,1983

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-(2-fluorophenyl)-S-methylisothiourea
  • Ethyl propiolate

DownStream

Related Compounds

  • N-[2-(6-bromo-1H-indol-1-yl)ethyl]-3,5-dimethyl-4-isoxazolecarboxamide
  • 1-(6-chloropyridazin-3-yl)-N-(5,6-dihydro-4H-cyclopenta[d][1,3]thiazol-2-yl)piperidine-3-carboxamide
  • 2-Amino-3-chloro-6-methoxybenzoic acid
  • N-{3-[4-(4-chlorophenyl)-4-hydroxypiperidino]-3-oxopropyl}-2-pyrazinecarboxamide
  • 5-oxo-N-[5-([1,2,4]triazolo[4,3-a]pyridin-3-yl)pentyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide
  • 2-[(4-phenylpiperazin-1-yl)methyl]-6-(thiophen-2-yl)pyridazin-3(2H)-one
  • I(3)-Ethyltetrahydro-2H-pyran-4-propanol
  • N-(4-fluorophenyl)-1-(1H-tetrazol-1-yl)cyclohexanecarboxamide
  • N-[2-(1H-1,3-benzimidazol-1-yl)ethyl]-2-[1-(1H-1,2,3,4-tetraazol-1-ylmethyl)cyclohexyl]acetamide
  • N-{3-[(1-methyl-1H-imidazol-2-yl)carbonyl]phenyl}-1-(1H-tetrazol-1-yl)cyclohexanecarboxamide
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