5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(4-morpholinyl)-a-lyxo-hexopyranosyl]oxy]-,hydrochloride, (8S,10S)- (9CI)

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Names

[ Name ]:
5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(4-morpholinyl)-a-lyxo-hexopyranosyl]oxy]-,hydrochloride, (8S,10S)- (9CI)

[Synonym ]:
Morpholinoadriamycin
(8S,10S)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-10-[(2S,4S,5S,6S)-5-hydroxy-6-methyl-4-morpholin-4-yl-oxan-2-yl]oxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
842.4ºC at 760 mmHg

[ Molecular Formula ]:
C₃₁H₃₆ClNO₁₂

[ Molecular Weight ]:
650.07000

[ Flash Point ]:
463.2ºC

[ Exact Mass ]:
649.19300

[ PSA ]:
192.52000

[ LogP ]:
1.11470

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9426040

CHEMICAL NAME :: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-8-(hydroxyacetyl)-1-methoxy-10-(( 2,3,6-trideoxy- 3-(4-morpholinyl)-alpha-lyxo-hexopyranosyl)oxy)-6,8,1 1-trihydroxy-, hydrochloride, (8S-cis)-

CAS REGISTRY NUMBER :: 89196-04-3

LAST UPDATED :: 199303

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C31-H35-N-O12.Cl-H

MOLECULAR WEIGHT :: 650.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Musculoskeletal - other changes Nutritional and Gross Metabolic - dehydration

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-211144

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 90 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Musculoskeletal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-211144

Related Compounds

Neoisomenthyl acetate
2,2-Dimethyl-6-(3-methoxy-phenyl)-[1,3]dioxin-4-one
1-(6-Amino-3,4-dihydro-1(2H)-quinolinyl)-3,3,3-trifluoro-1-propanone
1-(6-Amino-3,4-dihydro-1(2H)-quinolinyl)-3-phenyl-1-propanone
4-methyl-N-(2,2,2-trifluoroethyl)-1,3-thiazol-2-amine
3-methoxy-N-(5-((2-((2-methoxyethyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-1-methyl-1H-pyrazole-4-carboxamide
1-Cyclohexanecarbonyl-2,3-dihydro-1H-indol-5-amine
1-Cyclobutanecarbonyl-2,3-dihydro-1H-indol-5-amine
1-Cyclopentanecarbonyl-2,3-dihydro-1H-indol-5-amine
(1S,3S,4R)-1-cyclopropyl-4-methylcyclohexane-1,3-diol

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