15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one

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Names

[ CAS No. ]:
892-17-1

[ Name ]:
15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one

[Synonym ]:
11-methyl-16,17-dihydro-15H-cyclopenta<a>-phenanthren-17-one
11-Methyl-15,16-dihydrocyclopenta<a>phenanthren-17-one
11-Methyl-15,16-dihydro-cyclopenta<a>phenanthren-17-on

Chemical & Physical Properties

[ Density]:
1.234g/cm3

[ Boiling Point ]:
470.4ºC at 760 mmHg

[ Molecular Formula ]:
C18H14O

[ Molecular Weight ]:
246.30300

[ Flash Point ]:
211.3ºC

[ Exact Mass ]:
246.10400

[ PSA ]:
17.07000

[ LogP ]:
4.43030

[ Index of Refraction ]:
1.723

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GY5775000
CHEMICAL NAME :
17H-Cyclopenta(a)phenanthren-17-one, 15,16-dihydro-11-methyl-
CAS REGISTRY NUMBER :
892-17-1
LAST UPDATED :
199612
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C18-H14-O
MOLECULAR WEIGHT :
246.32
WISWESSER LINE NOTATION :
L E5 B666 FVT&&&J N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2000 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46 mg/kg/19W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg/4D-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
DNA adduct

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
500 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,984,1983

Safety Information

[ HS Code ]:
2914399090

Synthetic Route

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%


Related Compounds

  • O-{[1-(2-chloro-5-nitrophenyl)cyclopropyl]methyl}hydroxylamine
  • Dimethyl({2-[(oxiran-2-yl)methyl]-1,3-thiazol-5-yl}methyl)amine
  • 2,4-Dichloro-5-(3-chloroprop-1-en-2-yl)pyridine
  • 6-Amino-2-(propan-2-yl)quinolin-3-ol
  • 1-(3-methyl-3H-diazirin-3-yl)propan-2-amine
  • 1-[2-Methyl-4-(trifluoromethyl)phenyl]propan-2-ol
  • 3-(2-Methoxypyridin-3-yl)propan-1-ol
  • 1,1,1-Trifluoro-3-(5-nitrothiophen-2-yl)propan-2-one
  • (1S)-2-amino-1-(oxan-2-yl)ethan-1-ol
  • 2-Amino-2-(4-ethoxy-2-methylphenyl)propan-1-ol
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