15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one

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Names

[ CAS No. ]:
892-17-1

[ Name ]:
15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one

[Synonym ]:
11-methyl-16,17-dihydro-15H-cyclopenta<a>-phenanthren-17-one
11-Methyl-15,16-dihydrocyclopenta<a>phenanthren-17-one
11-Methyl-15,16-dihydro-cyclopenta<a>phenanthren-17-on

Chemical & Physical Properties

[ Density]:
1.234g/cm3

[ Boiling Point ]:
470.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₄O

[ Molecular Weight ]:
246.30300

[ Flash Point ]:
211.3ºC

[ Exact Mass ]:
246.10400

[ PSA ]:
17.07000

[ LogP ]:
4.43030

[ Index of Refraction ]:
1.723

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY5775000

CHEMICAL NAME :: 17H-Cyclopenta(a)phenanthren-17-one, 15,16-dihydro-11-methyl-

CAS REGISTRY NUMBER :: 892-17-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C18-H14-O

MOLECULAR WEIGHT :: 246.32

WISWESSER LINE NOTATION :: L E5 B666 FVT&&&J N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2000 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg/19W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg/50W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg/4D-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 500 ug/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,984,1983

Safety Information

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Related Compounds

Ethyl 4-(4-fluorophenyl)-2-(phenylcarbamoylamino)thiophene-3-carboxylate
(3-(Hydroxymethyl)piperidin-1-yl)(1-methylpiperidin-3-yl)methanone
Ethyl 4-propyl-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-carboxylate
3-(1-methyl-1H-1,2,3,4-tetrazol-5-yl)propan-1-amine
(4-Amino-3-methylbutyl)(methyl)(propan-2-yl)amine
2-Acetamido-4-ethyl-1,3-thiazole-5-carboxylic acid
3-Ethoxy-2-formamidopropanoic acid
N-Cyclohexyl-2,4-dimethyl-3-furancarboxamide
N-(Cyanomethyl)-2-(2,4-difluorophenyl)-N-phenylacetamide
(5-Fluoropyridin-3-yl)methanethiol

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