2-Butanone, 4-[(nitrosomethyl)amino]- (9CI)

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Names

[ CAS No. ]:
89367-15-7

[ Name ]:
2-Butanone, 4-[(nitrosomethyl)amino]- (9CI)

Chemical & Physical Properties

[ Density]:
1.12g/cm3

[ Boiling Point ]:
196.7ºC at 760 mmHg

[ Molecular Formula ]:
C5H10N2O2

[ Molecular Weight ]:
130.14500

[ Flash Point ]:
72.7ºC

[ Exact Mass ]:
130.07400

[ PSA ]:
58.53000

[ LogP ]:
0.66990

[ Index of Refraction ]:
1.484

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EL9154000
CHEMICAL NAME :
2-Butanone, 4-(methylnitrosamino)-
CAS REGISTRY NUMBER :
89367-15-7
LAST UPDATED :
199706
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C5-H10-N2-O2
MOLECULAR WEIGHT :
130.17
WISWESSER LINE NOTATION :
ONN1&2V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
705 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
770 mg/kg/38W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - colon tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
1377 mg/kg/34W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
700 umol/L
REFERENCE :
50EYAN "Structure-Activity Correlation as a Predictive Tool in Toxicology, Papers from a Symposium, 1981," Golberg, L., ed., Washington, DC, Hemisphere Pub. Corp., 1983 Volume(issue)/page/year: -,241,1983

Related Compounds

  • 2-Butanone, 4-amino-3-(aminomethyl)- (9CI)
  • 2-Butanone, 4-amino-3,3-dimethyl- (9CI)
  • 2-Butanone, 4-[(1-methylethyl)amino]- (9CI)
  • 2-Butanone, 4-amino-, N,N-bis(C7-9-branched and linear alkyl) derivs.
  • 2-Butanone, 4-amino-
  • 2-Butanone,4-amino-1-bromo-