NOMIFENSINE

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Names

[ CAS No. ]:
89664-20-0

[ Name ]:
NOMIFENSINE

[Synonym ]:
(-)-N-methylcystine
(1r)-l
Caulophyllin
(R)-(-)-2-Methyl-4-phenyl-8-amino-1,2,3,4-tetrahydroisochinolin
(1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
12-methyl-cytisin
Cytisine,12-methyl
(-)-cytisine
(-)-nomifensine
1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy
N-methyl cytisine
12-Methylcytisine
(-)-N-methycytisine
METHYLCYTISINE,N-(P)
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine

Chemical & Physical Properties

[ Melting Point ]:
179-181ºC

[ Molecular Formula ]:
C16H18N2

[ Molecular Weight ]:
238.32800

[ Exact Mass ]:
238.14700

[ PSA ]:
29.26000

[ LogP ]:
3.36520

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NW6801000
CHEMICAL NAME :
8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (R)-
CAS REGISTRY NUMBER :
89664-20-0
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H18-N2
MOLECULAR WEIGHT :
238.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
49500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,798,1987

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Nomifensine
  • 2-((2-aminobenzyl)(methyl)amino)-1-phenylethanone
  • 2-[(2-aminophenyl)methyl-methylamino]-1-phenylethanol
  • Formylaniline
  • 2-(methyliminomethyl)aniline
  • 2-[(Methylamino)methyl]aniline

DownStream

Related Compounds

  • Nomifensine
  • Nomifensine
  • Nomifensine M2
  • Nomifensine M3
  • Nomifensine HCl
  • (S)-nomifensine
  • 1h-Indole-1-carboxylic acid,5-(4-morpholinylmethyl)-,1,1-dimethylethyl ester
  • 1h-Indole-1-carboxylic acid,5-(4-piperidinyl)-,1,1-dimethylethyl ester
  • 5-Thiocarbamoyl-indole-1-carboxylic acid tert-butyl ester
  • 1h-Indole-1-carboxylic acid,5-[(ethoxyoxoacetyl)amino]-,1,1-dimethylethyl ester
  • 1h-Indole-1-carboxylic acid,6-fluoro-7-formyl-2,3-dihydro-,1,1-dimethylethyl ester
  • 1h-Indole-1-carboxylic acid,7-(1-piperazinyl)-,1,1-dimethylethyl ester
  • 1h-Indole-1-carboxylic acid,7-(3-aminopropyl)-2,3-dihydro-,1,1-dimethylethyl ester
  • 1h-Indole-2-carboxylic acid,5-chloro-1-[(2,3-dihydro-1h-indol-6-yl)methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-
  • 1h-Indole-3-acetic acid,a-amino-7-chloro-
  • 7-(trifluoromethyl)-1H-Indole-3-acetic acid
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