Salicylaldehyde

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Names

[ CAS No. ]:
90-02-8

[ Name ]:
Salicylaldehyde

[Synonym ]:
salicyaldehyde
FEMA 3004
2-hydroxylphenylaldehyde
2-hydroxyl-1-benzaldehyde
MFCD00003317
Salicylaldehyde
2-FORMYLPHENOL
salicyladehyde
Salicylal
o-Formylphenol
EINECS 201-961-0
SALICYLIALDENYDE
2-hydroxy-benzaldehyde
SALICYLALDEHYD
ortho-hydroxybenzaldehyde

Chemical & Physical Properties

[ Density]:
1.146 g/mL at 25 °C(lit.)

[ Boiling Point ]:
197 °C(lit.)

[ Melting Point ]:
1-2 °C(lit.)

[ Molecular Formula ]:
C₇H₆O₂

[ Molecular Weight ]:
122.12100

[ Flash Point ]:
170 °F

[ Exact Mass ]:
122.03700

[ PSA ]:
37.30000

[ LogP ]:
1.20470

[ Vapour density ]:
4.2 (vs air)

[ Vapour Pressure ]:
1 mm Hg ( 33 °C)

[ Index of Refraction ]:
n20/D 1.573(lit.)

[ Stability ]:
Stable. Combustible. Incompatible with strong bases, strong reducing agents, strong acids, strong oxidizing agents.

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN5250000

CHEMICAL NAME :: Salicylaldehyde

CAS REGISTRY NUMBER :: 90-02-8

BEILSTEIN REFERENCE NO. :: 0471388

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C7-H6-O2

MOLECULAR WEIGHT :: 122.13

WISWESSER LINE NOTATION :: VHR BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,903,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,903,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,903,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,903,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 504 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533438

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 231 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 16,371,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,903,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533438 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 38,209,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 38,209,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80207 No. of Facilities: 49 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 418 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80207 No. of Facilities: 723 (estimated) No. of Industries: 9 No. of Occupations: 6 No. of Employees: 4597 (estimated) No. of Female Employees: 234 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H411

[ Precautionary Statements ]:
P273-P301 + P312 + P330-P391-P501

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R21/22;R36/38

[ Safety Phrases ]:
S26-S36/37-S36/37/39

[ RIDADR ]:
3082

[ WGK Germany ]:
2

[ RTECS ]:
VN5250000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

[acetyloxy-(2-acetyloxyphenyl)methyl] acetate
trifuoro-methanesulfonic acid 2-formyl-phenyl ester
salicyl alcohol
o-cresol
salicylaldehyde, oxime
VHR BO2U1
o-Anisaldehyde
3-(t-Butyl)phenol
MAGNESIUM METHOXIDE

DownStream

3-(2-benzothiazolyl)-2H-1-benzopyran-2-one
benzene-1,2-diol,formic acid
cis,cis-muconic acid
3-(2-hydroxyphenyl)-2-methylprop-2-enoic acid
sodium,2-[[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]ethyl sulfate
2-ETHOXYCHROMAN
2-[2-(2-chlorophenyl)ethyl]phenol
2-Hex-1-ynyl-benzaldehyde
3,6-dibromo-2-phenylchromen-4-one
4-[[(Z)-indol-3-ylidenemethyl]amino]-N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]benzohydrazide

Articles

3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.

Bioorg. Med. Chem. 15 , 2006-15, (2007)

Phenoloxidase (PO), also known as tyrosinase, is a key enzyme in insect development, responsible for catalyzing the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-q...

Highly selective silver nanoparticles based label free colorimetric sensor for nitrite anions.

Anal. Chim. Acta 842 , 57-62, (2014)

Highly selective label free colorimetric sensor based on AgNPs stabilized by phenolic chelating ligand, N,N'-bis(2-hydroxybenzyl)-1,2-diaminobenzene (1), for NO(2-) anions has been developed. Addition...

Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation.

Cancer Res. 75 , 2211-21, (2015)

Iron homeostasis is disrupted in multiple myeloma, a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here, we systematically analyzed iron gene expression signature and demonstrated ...

salicylaldehyde-d1
salicylaldehyde-d1
Co(salicylaldehyde)2
bromosalicylaldehyde
nitrosalicylaldehyde
salicylaldehyde imine
2-(4-Fluorophenyl)-delta-hydroxy-5-(1-methylethyl)-beta-oxo-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester
(3S,4aR,7aS,8aS,8bS,11R,11aR,13aS,13bR)-3-Hydroxy-11a,13b-dimethyl-11-[(2R)-6-methylheptan-2-yl]hexadecahydro-6H-cyclopenta[1,2]phenanthro[9,8a-d][1,3]oxathiole-6-thione
N-(2-furanylmethyl)-N-2-propyn-1-ylcarbamic acid 1,1-dimethylethyl ester
tert-butyl (2E)-3-(3,5-dichlorophenyl)prop-2-enoate
2-Hydroxy-3,3-difluoro-3-phenylpropiononitrile
2,6,6-Trimethyl-1-[3-methyl-2-butenoyl]-1-cyclohexene
N,3-dimethylpyridine-2-carboxamide
6-chloro-N-(2-methylpropyl)pyrazin-2-amine
5-[benzyl(furan-2-ylmethyl)amino]-2-(ethylsulfonyl)-N-(4-methylphenyl)pyrimidine-4-carboxamide
1-methyl-1H-1,2,3-benzotriazole-7-sulfonyl chloride

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