Guaiacol

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Names

[ CAS No. ]:
90-05-1

[ Name ]:
Guaiacol

[Synonym ]:
5-fluoro-2,3-dihydro-1h-isoindole
2-Methoxyphenol
methoxyphenol
2,3-dihydro-6-fluoro-1H-indole
o-Methoxyphenol
Guaiacol
MFCD00002185
Indoline, 6-fluoro-
2-Hydroxyanisole
2-Methoxy-phenol
o-Methylcatechol
2,3-dihydro-6-fluoroindole
Catechol, Methyl
o-methoxy-Phenol
6-Fluor-indolin
6-Fluoroindoline
ORTHO-METHOXYPHENOL
6-fluoro-2,3-dihydro-indole
Phenol, 2-methoxy-
o-methoxy catechol
O-Methyl catechol
1H-Indole, 6-fluoro-2,3-dihydro-
Indoline,6-fluoro
Methylcatechol
EINECS 201-964-7
Catechol monomethyl ether
o-Hydroxyanisole

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
207.5±29.0 °C at 760 mmHg

[ Melting Point ]:
26-29 °C(lit.)

[ Molecular Formula ]:
C₇H₈O₂

[ Molecular Weight ]:
124.14

[ Flash Point ]:
79.3±24.3 °C

[ PSA ]:
29.46000

[ LogP ]:
2.11

[ Vapour density ]:
4.27 (vs air)

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.538

[ Storage condition ]:
Refrigerator

[ Stability ]:
Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
17 g/L (15 ºC)

[ Freezing Point ]:
28℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL7525000

CHEMICAL NAME :: Phenol, o-methoxy-

CAS REGISTRY NUMBER :: 90-05-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C7-H8-O2

MOLECULAR WEIGHT :: 124.15

WISWESSER LINE NOTATION :: QR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 621 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7570 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21215 mg/kg/40D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 169,129,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2844 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 1596 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2844 No. of Facilities: 34 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 2101 (estimated) No. of Female Employees: 297 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319

[ Precautionary Statements ]:
P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
2810

[ WGK Germany ]:
1

[ RTECS ]:
SL7525000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2909500000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Methoxyphenylboronic acid
bromoanisole
iodoanisole
2-Chloroanisole
1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol
Vanillin
1,2-dimethoxy-4-[(2-methoxyphenoxy)methyl]benzene
Anisole
1,2-Dimethoxybenzene
Ortho-Hydroxyacetophenone

DownStream

3-(2-Methoxyphenyl)-1-propanol
4-butan-2-yl-2-methoxyphenol
4-Iodoguiacol
2-Iodo-6-methoxyphenol
1-[2-(2-METHOXYPHENOXY)ETHYL]-PIPERIDINE
1,2-dimethoxy-4-[(2-methoxyphenoxy)methyl]benzene
3-[(2-methoxyphenoxy)methyl]-4-phenyl-1H-1,2,4-triazole-5-thione
3-Isopropoxy-4-methoxy-benzaldehyde
5-chloro-2-methoxyphenol
3-Methoxy-4-propoxybenzaldehyde

Customs

[ HS Code ]: 2909500000

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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m-Guaiacol
P-GUAIACOL
guaiacol-d3
Guaiacol-d3
Guaiacol-d7
Guaiacol-d3
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4,6-Dichloro-2-isopropyl-5-methoxypyrimidine
5-Ethoxy-2-(methylthio)-4-pyrimidinamine
4-Bromo-2-chloro-1,1a,6,6a-tetrahydrocyclopropa[a]indene
2-(6-Amino-5-methoxypyridin-2-yl)propan-2-ol
4-Formyl-3-((2-(trimethylsilyl)ethoxy)methoxy)benzonitrile
7-Bromo-6-fluorobenzo[d][1,3]dioxol-5-amine
4-Bromo-N,2,6-trimethylbenzamide
3-(Benzyloxy)-2-bromo-5-methyl-4-nitropyridine
4-Bromo-5-methyl-1,2-benzenedimethanol