3,5-Dibromo-2-hydroxybenzaldehyde

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Names

[ CAS No. ]:
90-59-5

[ Name ]:
3,5-Dibromo-2-hydroxybenzaldehyde

[Synonym ]:
3,5-Dibromosalicylaldehyde
salicylaldehyde, 3,5-dibromo-
EINECS 202-003-4
MFCD00003318
Benzaldehyde, 3,5-dibromo-2-hydroxy-
3,5-Dibromo-2-hydroxybenzaldehyde

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
261.2±35.0 °C at 760 mmHg

[ Melting Point ]:
82-83.5 °C(lit.)

[ Molecular Formula ]:
C7H4Br2O2

[ Molecular Weight ]:
279.914

[ Flash Point ]:
111.7±25.9 °C

[ Exact Mass ]:
277.857788

[ PSA ]:
37.30000

[ LogP ]:
3.76

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.687

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU5609000
CHEMICAL NAME :
Benzaldehyde, 3,5-dibromo-2-hydroxy-
CAS REGISTRY NUMBER :
90-59-5
BEILSTEIN REFERENCE NO. :
1424739
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H4-Br2-O2
MOLECULAR WEIGHT :
279.93
WISWESSER LINE NOTATION :
VHR BQ CE EE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 10,528,1962

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H400

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39-S24/25

[ RIDADR ]:
UN 3077 9 / PGIII

[ WGK Germany ]:
3

[ RTECS ]:
CU5609000

[ HS Code ]:
2913000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Salicylaldehyde
  • 2-Methylbenzyl Alcohol
  • 2,4-Dibromophenol
  • Aminoform
  • tert-butyl 3-(3,5-dibromo-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate
  • Chloroacetyl chloride

DownStream

  • 3,5-dibromobenzene-1,2-diol
  • 6,8-dibromocoumarin-3-carboxylic acid
  • ALPHA,3,5-TRIBROMO-2-HYDROXYTOLUENE
  • 2,4-dibromo-6-(hydroxymethyl)phenol
  • ETHYL 6,8-DIBROMO-2-OXO-2H-CHROMENE-3-CARBOXYLATE
  • 6 8-DIBROMO-1' 3'-DIHYDRO-1' 3' 3'-TRI-&
  • Diethyl succinosuccinate
  • 1-(5,7-dibromobenzofuran-2-yl)ethanone
  • 2,4-Dibromo-6-[[[[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]Methyl][(S)-1-phenylethyl]amino]Methyl]phenol

Customs

[ HS Code ]: 2913000090

[ Summary ]:
HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0%

Articles

NMR studies of solvent-assisted proton transfer in a biologically relevant Schiff base: toward a distinction of geometric and equilibrium H-bond isotope effects.

J. Am. Chem. Soc. 128(10) , 3375-87, (2006)

The tautomeric equilibrium in a Schiff base, N-(3,5-dibromosalicylidene)-methylamine 1, a model for the hydrogen bonded structure of the cofactor pyridoxal-5'-phosphate PLP which is located in the act...

Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde.

Eur. J. Med. Chem. 58 , 323-31, (2012)

Eleven mononuclear copper(II), nickel(II), zinc(II) and cobalt(II) complexes of Schiff base ligands derived from 3,5-dibromosalicylaldehyde/3,5-dichlorosalicylaldehyde were synthesized and determined ...

Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1.

Mucosal Immunol. 8 , 1118-30, (2015)

While recent studies suggest that interleukin (IL)-1β production is modulated by macroautophagy or sensors of endoplasmic reticulum (ER) stress upon pro-inflammatory insult, autophagy and IL-1β produc...


More Articles

Related Compounds

  • 3,5-Dibromo-2-hydroxybenzaldehyde 4-phenyl thiosemicarbazone
  • 3,5-Dibromo-2-fluoro-4-hydroxybenzaldehyde
  • 3,5-Dibromo-2-methoxybenzoic acid
  • 3,5-dibromo-2-hydroxy-N-(4-isothiocyanatophenyl)benzamide
  • 3,5-dibromo-2,2,6,6-tetramethylpiperidin-4-one,hydrobromide
  • 3,5-Dibromo-2,6-dimethylpyridine