AS-252424

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₄H₈FNO₄S

[ Molecular Weight ]:
305.281

[ Exact Mass ]:
305.015808

[ PSA ]:
104.84000

[ LogP ]:
2.14

[ Appearance of Characters ]:
yellow

[ Index of Refraction ]:
1.692

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >20mg/mL

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms.

Immunol. Res. 62 , 175-88, (2015)

PI3K inhibitors have emerged as potential therapeutic tools for a variety of diseases, and thus, a vast array of compounds with specificity for different PI3K isoforms is being developed. Gaining know...

Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.

J. Med. Chem. 49 , 3857-3871, (2006)

Class I phosphoinositide 3-kinases (PI3Ks), in particular PI3Kgamma, have become attractive drug targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan-2-ylmethyle...

Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms.

PLoS ONE 6 , e24663, (2011)

Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disease characterized by an accumulation of fibroblasts and myofibroblasts in the alveolar wall. Even though the pathogenesis of...

More Articles