5-Methyl-3-(pyridin-2-yl)benzo[5,6][1,2]thiazino[3,4-e][1,3]oxazine-2,4(3H,5H)-dione 6,6-dioxide

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Names

[ CAS No. ]:
90101-16-9

[ Name ]:
5-Methyl-3-(pyridin-2-yl)benzo[5,6][1,2]thiazino[3,4-e][1,3]oxazine-2,4(3H,5H)-dione 6,6-dioxide

[Synonym ]:
Droxicam
2H,5H-1,3-Oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione, 5-methyl-3-(2-pyridinyl)-, 6,6-dioxide
5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4-dione
5-Methyl-3-(2-pyridinyl)-2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
5-Methyl-3-(pyridin-2-yl)-2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
Ombolan
5-Methyl-3-(2-pyridinyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-Dioxide
5-Methyl-3-(pyridin-2-yl)benzo[5,6][1,2]thiazino[3,4-e][1,3]oxazine-2,4(3H,5H)-dione 6,6-dioxide

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
554.7±60.0 °C at 760 mmHg

[ Melting Point ]:
259-261°

[ Molecular Formula ]:
C16H11N3O5S

[ Molecular Weight ]:
357.34

[ Flash Point ]:
289.3±32.9 °C

[ Exact Mass ]:
357.041931

[ PSA ]:
110.86000

[ LogP ]:
1.11

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.748

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6505000
CHEMICAL NAME :
2H,5H-1,3-Oxazino(5,6-c)(1,2)benzothiazine-2,4(3H)-di one, 5-methyl-3-(2-pyridinyl)-, 6,6-dioxide
CAS REGISTRY NUMBER :
90101-16-9
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C16-H11-N3-O5-S
MOLECULAR WEIGHT :
357.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1434 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4563452
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6192 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4563452

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Triphosgene
  • Piroxicam

DownStream

Related Compounds

  • Ethyl 1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-1,2,3-triazole-4-carboxylate
  • 3-Isoxazolecarboxylic acid, 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2,5-dihydro-
  • 2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl I+/--bromobenzenepropanoate
  • [3-(2,4-Difluoro-6-methoxyphenyl)-2,2-dimethylcyclopropyl]methanamine
  • 1,3-Piperidinedicarboxylic acid, 4-fluoro-3-methyl-, 1-(1,1-dimethylethyl) 3-ethyl ester
  • 3-(4-Fluoro-3-nitrophenyl)-1,2-oxazol-5-amine
  • 3-(5-Methylpyridin-2-yl)oxolane-2,5-dione
  • N-[8-(Phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]glycine 2-(2-methylpropylidene)hydrazide
  • 1-Methyl-1H-pyrazole-5-carboxylic acid 2-[(2-hydroxy-5-methoxyphenyl)methylene]hydrazide
  • 6-(2,5-Dimethoxyphenyl)-3-[4-(1-methylethyl)phenyl]imidazo[2,1-b]thiazole-5-acetonitrile
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