DNA ligase

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
402.3±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₁N₃

[ Molecular Weight ]:
233.268

[ Flash Point ]:
182.5±18.9 °C

[ Exact Mass ]:
233.095291

[ LogP ]:
2.13

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
20°C

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression.

Cell 151(7) , 1474-87, (2012)

DNA Ligase IV is responsible for sealing of double-strand breaks (DSBs) during nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs, thereby serving as a strategy to...

One-step highly sensitive florescence detection of T4 polynucleotide kinase activity and biological small molecules by ligation-nicking coupled reaction-mediated signal amplification.

Biosens. Bioelectron. 47 , 218-24, (2013)

DNA phosphorylation, catalyzed by polynucleotide kinase (PNK), plays significant regulatory roles in many biological events. Herein, using T4 PNK as a model target, we describe a one-step, highly sens...

Suppression of Ku70/80 or Lig4 leads to decreased stable transformation and enhanced homologous recombination in rice.

New Phytol. 196(4) , 1048-59, (2012)

Evidence for the involvement of the nonhomologous end joining (NHEJ) pathway in Agrobacterium-mediated transferred DNA (T-DNA) integration into the genome of the model plant Arabidopsis remains inconc...

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