Cathepsin D, from bovine spleen

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Names

[ Name ]:
Cathepsin D, from bovine spleen

[Synonym ]:
2-[(3-Hydroxy-2-butanyl)sulfanyl]-3-methyl-1,4-naphthoquinone
1,4-Naphthalenedione, 2-[(2-hydroxy-1-methylpropyl)thio]-3-methyl-
2-[(3-hydroxybutan-2-yl)sulfanyl]-3-methylnaphthalene-1,4-dione
MFCD00130749

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
432.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₆O₃S

[ Molecular Weight ]:
276.351

[ Flash Point ]:
215.3±28.7 °C

[ Exact Mass ]:
276.082001

[ LogP ]:
3.16

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.609

[ Storage condition ]:
20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

4-tert-Octylphenol stimulates the expression of cathepsins in human breast cancer cells and xenografted breast tumors of a mouse model via an estrogen receptor-mediated signaling pathway.

Toxicology 304 , 13-20, (2013)

Endocrine disrupting chemicals (EDCs) are defined as environmental compounds that modulate steroid hormone receptor-dependent responses an abnormal manner, resulting in adverse health problems for hum...

A periodate-cleavable linker for functional proteomics under slightly acidic conditions: application for the analysis of intracellular aspartic proteases.

J. Proteome Res. 12(1) , 199-207, (2013)

Specific elution of captured proteins greatly improves the quality of proteomic data obtained from pull-downs by avoiding signals from nonspecific proteins, thus allowing more sensitive identification...

Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.

Cell Death Dis. 4 , e507, (2013)

Colorectal carcinoma (CRC) is one of the most common causes of cancer-related mortality. Short-chain fatty acids secreted by dietary propionibacteria from the intestine, such as acetate, induce apopto...

1-(2-((4-chlorobenzyl)amino)-2-oxoethyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
1-({[(4-fluorophenyl)methyl]carbamoyl}methyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
1-(2-((2-chlorobenzyl)amino)-2-oxoethyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
1-({[2-chloro-5-(trifluoromethyl)phenyl]carbamoyl}methyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
1-(2-((5-chloro-2-methoxyphenyl)amino)-2-oxoethyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
1-{[(3,4-difluorophenyl)carbamoyl]methyl}-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
1-(2-((3,4-dimethoxyphenyl)amino)-2-oxoethyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
1-{[(4-bromophenyl)carbamoyl]methyl}-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
N-(4-methoxyphenyl)-6-oxo-1-({[4-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,6-dihydropyridazine-3-carboxamide
1-(2-((4-chlorophenyl)amino)-2-oxoethyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide

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