Clostripain from Clostridium histolyticum

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Names

[ Name ]:
Clostripain from Clostridium histolyticum

[Synonym ]:
MFCD00130814
Pyrrolo[3,4-c]carbazole-1,3(2H,3aH)-dione, 9-bromo-4,5,6,10c-tetrahydro-2-phenyl-4-(3,4,5-trimethoxyphenyl)-
9-Bromo-2-phenyl-4-(3,4,5-trimethoxyphenyl)-4,5,6,10c-tetrahydropyrrolo[3,4-c]carbazole-1,3(2H,3aH)-dione

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
751.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₂₅BrN₂O₅

[ Molecular Weight ]:
561.423

[ Flash Point ]:
408.4±32.9 °C

[ Exact Mass ]:
560.094666

[ LogP ]:
4.55

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.669

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Determination of the cytotoxic effect of Clostridium histolyticum culture supernatant on HeLa cells in the presence of protease inhibitors.

FEMS Immunol. Med. Microbiol. 45(2) , 137-42, (2005)

Clostridium histolyticum culture supernatant contains numerous enzymes, which exert a cytotoxic effect on host cells. This includes lethal toxin, clostripain and high-potassium-sensitive toxin. Since ...

High-level production and purification of clostripain expressed in a virulence-attenuated strain of Clostridium perfringens.

Protein Expr. Purif. 76(1) , 83-9, (2011)

Clostripain (CLO) produced by Clostridium histolyticum is an arginine-specific endopeptidase with the potential for applicability to diverse medical and industrial uses. In this study, we developed an...

Protease-mediated ligation of abiotic oligomers.

J. Am. Chem. Soc. 127(49) , 17132-3, (2005)

We demonstrate that proteases can catalyze the ligation of peptidomimetic oligomers. The enzyme clostripain was used to facilitate the native ligation of N-substituted glycine oligomers, or peptoids. ...

N-{3-Amino-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-N-methylacetamide
N-(3-Amino-4-{[(4,4-difluorocyclohexyl)methyl]amino}phenyl)acetamide
Tert-butyl ((4-fluorocyclohex-3-en-1-yl)methyl)carbamate
2-tert-Butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-amine
6-Chloro-2-methoxy-4-methyl-nicotinic acid methyl ester
4-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester
3-Chloro-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid methyl ester
3,5-Bis-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid methyl ester
Methyl 5-chloro-3-(3-(trifluoromethyl)phenyl)picolinate
3-Chloro-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid

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