(-)-Indolactam V

Suppliers

Names

[ Name ]:
(-)-Indolactam V

[Synonym ]:
(2S,5S)-5-(hydroxymethyl)-1-methyl-2-(propan-2-yl)-1,2,4,5,6,8-hexahydro-3H-[1,4]diazonino[7,6,5-cd]indol-3-one
3H-1,4-Diazonino[7,6,5-cd]indol-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)-
(-)-indolactam
Indolactam V
(2S,5S)-5-(Hydroxymethyl)-2-isopropyl-1-methyl-1,2,4,5,6,8-hexahydro-3H-[1,4]diazonino[7,6,5-cd]indol-3-one

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
584.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₃N₃O₂

[ Molecular Weight ]:
301.383

[ Flash Point ]:
307.0±30.1 °C

[ Exact Mass ]:
301.179016

[ PSA ]:
68.36000

[ LogP ]:
0.75

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.590

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8547000

CHEMICAL NAME :: 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1- methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))-

CAS REGISTRY NUMBER :: 90365-57-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H23-N3-O2

MOLECULAR WEIGHT :: 301.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 44,1029,1991

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Structural basis of RasGRP binding to high-affinity PKC ligands.

J. Med. Chem. 45(4) , 853-60, (2002)

The Ras guanyl releasing protein RasGRP belongs to the CDC25 class of guanyl nucleotide exchange factors that regulate Ras-related GTPases. These GTPases serve as switches for the propagation and dive...

Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.

Bioorg. Med. Chem. 12(17) , 4575-83, (2004)

Recent investigations discovered nonkinase-type phorbol ester receptors, RasGRPs, chimaerins, and Unc13s. Phorbol ester binding occurs at the cysteine-rich sequences of about 50 residues in the C1 dom...

Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.

Curr. Pharm. Des. 10(12) , 1371-85, (2004)

Protein kinase C (PKC) isozymes (alpha, betaI, betaII, gamma, delta, epsilon, eta, theta) are major receptors of tumor promoters and also play a crucial role in cellular signal transduction via the se...

(-)-n-Hexyl indolactam V
(+)-ETHYL(R)-3-HYDROXY-3-PHENYLPROPIONATE
(-)-indolactam-Ile
manganese(V) chloride
antimony(V) chloride water
trinitratooxovanadium(V)
tert-butyl (4S)-4-(hydrazinecarbonyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
1-{5-Chlorothieno[3,2-b]pyridin-2-yl}cyclopropane-1-carbonitrile
3-{5-Chlorothieno[3,2-b]pyridin-2-yl}-1,1-difluoropropan-2-amine
1-(2,6-Dichloropyridin-4-yl)-2,2-difluoroethan-1-one
1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methoxybutanoyl]azetidine-2-carboxylic acid
[1-(4-Bromo-5-chlorothiophen-2-yl)cyclopropyl]methanamine
[1-(6-Chloropyridin-3-yl)-3,3-difluorocyclobutyl]methanamine
5-bromo-3-[(cyclopropylamino)methyl]-1-methyl-1H-indole-2-carbonitrile
2-[1-(5-Bromo-1,3-thiazol-2-yl)cyclopropyl]propan-2-amine
O-[1-(4-bromo-5-methylthiophen-2-yl)ethyl]hydroxylamine

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.