Xaliproden hydrochloride

[ Boiling Point ]:
487.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₄H₂₃ClF₃N

[ Molecular Weight ]:
417.89400

[ Flash Point ]:
248.8ºC

[ Exact Mass ]:
417.14700

[ PSA ]:
3.24000

[ LogP ]:
6.93030

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UT8405666

5-HT1A receptors are involved in the effects of xaliproden on G-protein activation, neurotransmitter release and nociception.

Br. J. Pharmacol. 158(1) , 232-42, (2009)

Xaliproden (SR57746A) is a 5-HT(1A) receptor agonist and neurotrophic agent that reduces oxaliplatin-mediated neuropathy in clinical trials. The present study investigated its profile on in vitro tran...

Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats.

Invest. Radiol. 37(6) , 321-7, (2002)

The neurotrophic effect of Xaliproden has been followed using sequential cerebral magnetic resonance imaging (MRI) in rats with vincristine-induced brain lesion as a model of Alzheimer disease.Ninetee...

The neuroprotective agent SR 57746A abrogates experimental autoimmune encephalomyelitis and impairs associated blood-brain barrier disruption: implications for multiple sclerosis treatment.

Proc. Natl. Acad. Sci. U. S. A. 96(22) , 12855-9, (1999)

Experimental autoimmune encephalomyelitis (EAE) is a T cell autoimmune disorder that is a widely used animal model for multiple sclerosis (MS) and, as in MS, clinical signs of EAE are associated with ...

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