Ribonuclease H, from Escherichia coli

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Names

[ CAS No. ]:
9050-76-4

[ Name ]:
Ribonuclease H, from Escherichia coli

[Synonym ]:
MFCD00132186

Chemical & Physical Properties

[ Storage condition ]:
−20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

Articles

Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors.

Clin. Infect. Dis. 55(5) , 737-45, (2012)

It is not known how often mutations in the connection and ribonuclease H domains of reverse transcriptase (RT) emerge with failure of first-line antiretroviral therapy (ART) in subtype C human immunod...

Metallobiochemistry of the magnesium ion. Characterization of the essential metal-binding site in Escherichia coli ribonuclease H.

Eur. J. Biochem. 219 , 253-60, (1994)

Ribonuclease H (Escherichia coli) contains one strong magnesium-binding site, as determined by metal-titration experiments monitored by high field 1H-NMR and also by direct titration calorimetry. Kine...

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity

Bioorg. Med. Chem. Lett. 22(12) , 3988-92, (2012)

We report herein the synthesis of a series of 3-hydroxyquinolin-2(1H)-one derivatives. Esters and amide groups were introduced at position 4 of the basis scaffold and some modulations of the benzenic ...