rhizoxin

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Names

[ CAS No. ]:
90996-54-6

[ Name ]:
rhizoxin

[Synonym ]:
4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13] heneicos-14-ene-6,19-dione, 10-hydroxy-8-[2-methoxy- 1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7- octatrienyl]-11,16-dimethyl-, [1S-[1R*,3R*,5S*, 8R*(1R*,2S*,3E,5E,7E),10R*,11S*,13S*,14E,16S*,17S*]]-
WF-1360
E-87/101

Chemical & Physical Properties

[ Density]:
1.165g/cm3

[ Boiling Point ]:
799.7ºC at 760mmHg

[ Molecular Formula ]:
C35H47NO9

[ Molecular Weight ]:
625.74900

[ Flash Point ]:
437.5ºC

[ Exact Mass ]:
625.32500

[ PSA ]:
133.15000

[ LogP ]:
5.04540

[ Index of Refraction ]:
1.539

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VI1800000
CHEMICAL NAME :
Rhizoxin
CAS REGISTRY NUMBER :
90996-54-6
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C35-H47-N-O9
MOLECULAR WEIGHT :
625.83

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3700 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Skin and Appendages - hair
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 ug/kg/10D-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Non-mammalian species Embryo
DOSE/DURATION :
16 umol/L
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 40,66,1987

Related Compounds

  • palmitoylrhizoxin