Benzhydrol

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Names

[ CAS No. ]:
91-01-0

[ Name ]:
Benzhydrol

[Synonym ]:
1,1-diphenylmethanol
EINECS 202-033-8
Benzenemethanol, α-phenyl-
benzhydrylalcohol
a-Phenylbenzenemethanol
a-Phenylbenzyl Alcohol
BENZOHYDROL
diphenyl methylol
benzydrol
hydroxy-diphenyl methane
Diphenylmethanol
diphenyl-methanol
Benzhydrol
BNEZHYDROL
MFCD00004488
DIPHENYLCARBINOL
Ebastine Impurity 1

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
299.0±0.0 °C at 760 mmHg

[ Melting Point ]:
65-67 °C(lit.)

[ Molecular Formula ]:
C13H12O

[ Molecular Weight ]:
184.23

[ Flash Point ]:
140.8±15.1 °C

[ Exact Mass ]:
184.088821

[ PSA ]:
20.23000

[ LogP ]:
2.74

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DC7452000
CHEMICAL NAME :
Benzhydrol
CAS REGISTRY NUMBER :
91-01-0
BEILSTEIN REFERENCE NO. :
1424379
LAST UPDATED :
199712
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C13-H12-O
MOLECULAR WEIGHT :
184.25
WISWESSER LINE NOTATION :
QYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,713,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,713,1979
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,405,1925 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83171 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 249 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
DC7452000

[ HS Code ]:
2906210000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (Trimethylsiloxy)diphenylmethane
  • Benzophenone
  • Triphenylboroxin
  • Benzaldehyde
  • Diphenylmethane
  • Phenylboronic acid
  • Bromobenzene
  • TRIMETHYL(PHENYL)TIN
  • Phenyltrimethoxysilane
  • 2-benzhydryloxyoxane

DownStream

  • 1-(2-benzhydryloxyethyl)piperidine-3-carboxylic acid
  • (S)-(+)-Modafinic acid
  • N-DIPHENYLMETHYLACRYLAMIDE
  • 3,3-Diphenylpropanoic acid
  • (thiocyanato)(diphenyl)methane
  • benzhydryl isothiocyanate
  • Benzophenone oxime
  • Benzhydryl 2-chloroethyl ether
  • Tritanol
  • Triphenylmethane

Customs

[ HS Code ]: 2906299090

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Semi-quantitative profile of regioisomeric monohydroxydiphenylmethane metabolites in rat urine, faeces and bile.

Xenobiotica 11(6) , 425-32, (1981)

1. Urine and faeces, and two-hour bile samples from adult male rats dosed with [14C]diphenylmethane were analysed for benzhydrol and 2- and 4-hydroxydiphenyl-methane by silica gel GF t.l.c. and 14C-de...

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors.

Bioorg. Med. Chem. 19 , 1930-1949, (2011)

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds...

Calorimetric study of glass transition in molecular liquids consisting of globular associates: dicyclorohexylmethanol and tricyclohexylmethanol.

J. Phys. Chem. B 116(13) , 3938-43, (2012)

Heat capacities of liquids and liquid-quenched glasses (LQGs) of dicyclorohexylmethanol (DCHM) and tricyclohexylmethanol (TCHM) were measured by adiabatic calorimetry. Upon cooling the liquid compound...


More Articles

Related Compounds

  • Benzhydrol
  • Benzhydrol-d5
  • Benzhydrol-1-d
  • Benzhydrol ether
  • 3-Jod-benzhydrol
  • Chlorobenzhydrol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1-(Furan-3-yl)-3-oxocyclobutane-1-carboxylic acid
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • rac-(1R,2S)-2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxybutanamido]methyl}cyclopentane-1-carboxylic acid
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5,5-dimethylhexanamido]-2-methylpropanoic acid